Emerging mechanisms of cell competition.
Emerging mechanisms of cell competition.
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DOI：
10.1038/s41576-020-0262-8
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Baker NE
中科院分区：
文献类型：
--
作者：
Baker NE
组织内细胞的生长和存活可能会受到不同细胞克隆之间“细胞竞争”的影响。这种现象最初是在黑腹果蝇的野生型细胞和核糖体蛋白（Rp）基因突变的细胞之间发现的。然而，竞争也会影响上皮极性基因突变的黑腹果蝇细胞，以及暴露于 Salvador-Warts-Hippo 肿瘤抑制途径突变或 Myc 表达水平升高的“超级竞争者”细胞的野生型细胞。最近，细胞竞争和超级竞争在哺乳动物发育、器官稳态和癌症中得到了认识。遗传和细胞生物学研究表明，细胞竞争的机制包括“不同”细胞的分子识别、不同细胞群之间的信号失衡以及不同生长速率的机械后果；这些机制还可能涉及先天免疫蛋白、p53 和翻译变化。组织内细胞的生长和存活可能受到不同细胞克隆之间竞争的影响。遗传和细胞生物学研究表明，细胞竞争可能是通过“不同”细胞的分子识别、细胞群之间的信号失衡或差异生长速率的机械后果而发生的。
The growth and survival of cells within tissues can be affected by ‘cell competition’ between different cell clones. This phenomenon was initially recognized between wild type cells and cells with mutations in ribosomal protein (Rp) genes in Drosophila melanogaster. However, competition also affects D. melanogaster cells with mutations in epithelial polarity genes, and wild type cells exposed to ‘super-competitor’ cells with mutation in the Salvador–Warts–Hippo tumour suppressor pathway or expressing elevated levels of Myc. More recently, cell competition and super-competition were recognized in mammalian development, organ homeostasis and cancer. Genetic and cell biological studies have revealed that mechanisms underlying cell competition include the molecular recognition of ‘different’ cells, signaling imbalances between distinct cell populations, and mechanical consequences of differential growth rates; these mechanisms may also involve innate immune proteins, p53, and changes in translation. The growth and survival of cells within tissues can be influenced by competition between different cell clones. Genetic and cell biological studies suggest that cell competition may occur through the molecular recognition of ‘different’ cells, signalling imbalances between cell populations or the mechanical consequences of differential growth rates.
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