Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury.
Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury.
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DOI：
10.1038/ki.2009.422
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发表时间：
2010-04
影响因子：
19.6
通讯作者：
Bonventre, Joseph V.
中科院分区：
文献类型：
--
作者：
Ferguson, Michael A.;Vaidya, Vishal S.;Waikar, Sushrut S.;Collings, Fitz B.;Sunderland, Kelsey E.;Gioules, Costas J.;Bonventre, Joseph V.
急性肾损伤（AKI）是一种常见疾病，发病率和死亡率显着相关。传统肾功能障碍标志物的不敏感性和非特异性阻碍了及时诊断、肾损伤严重程度的估计以及可能的治疗药物的施用。在这里，我们确定了尿肝型脂肪酸结合蛋白（L-FABP）的预后能力，并进一步表征了其作为 AKI 生物标志物的敏感性和特异性。最初的蛋白质印迹研究发现，确诊 AKI 的患者尿 L-FABP 增加。一项更广泛的横断面研究发现，与 62 名没有 AKI 临床证据的患者相比，92 名确诊 AKI 患者的尿 L-FABP（标准化为尿肌酐）显着增加。在住院患者中，尿液 L-FABP 对 AKI 的诊断性能（通过受试者工作特征曲线下面积评估）为 0.93。这与其他已确定的 AKI 生物标志物（如肾损伤分子 1、中性粒细胞明胶酶相关脂质运载蛋白、N-乙酰基-β-氨基葡萄糖苷酶和白细胞介素 18）相比具有优势。我们的研究表明，预后不良（定义为需要肾脏替代治疗或死亡或肾脏替代治疗的复合终点）的患者中，经年龄调整的尿 L-FABP 水平显着较高。
Acute kidney injury (AKI) is a common condition with significant associated morbidity and mortality. The insensitivity and non-specificity of traditional markers of renal dysfunction prevent timely diagnosis, estimation of the severity of renal injury, and the administration of possible therapeutic agents. Here, we determine the prognostic ability of urinary liver-type fatty acid-binding protein (L-FABP), and further characterize its sensitivity and specificity as a biomarker of AKI. Initial western blot studies found increased urinary L-FABP in patients with confirmed AKI. A more extensive cross-sectional study found significant increases in urinary L-FABP, normalized to urinary creatinine, in 92 patients with established AKI compared with 62 patients without clinical evidence of AKI. In hospitalized patients, the diagnostic performance of urinary L-FABP for AKI, assessed by the area under the receiver operating characteristic curve, was 0.93. This compares favorably with other established biomarkers of AKI such as kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, N-acetyl-β-glucosaminidase, and interleukin-18. Our study shows that age-adjusted urinary L-FABP levels were significantly higher in patients with poor outcome, defined as the requirement for renal replacement therapy or the composite end point of death or renal replacement therapy.
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影响因子：
5.9
作者：
Chertow, GM;Levy, EM;Daley, J
通讯作者：
Daley, J
DOI：
10.1097/01.asn.0000067652.51441.21
发表时间：
2003-06-01
影响因子：
13.6
作者：
Bonventre, JV
通讯作者：
Bonventre, JV
影响因子：
120.7
作者：
Chertow, GM;Lee, J;Bates, DW
通讯作者：
Bates, DW
影响因子：
38.9
作者：
de Mendonça, A;Vincent, JL;Cantraine, F
通讯作者：
Cantraine, F
影响因子：
5.9
作者：
HOU, SH;BUSHINSKY, DA;HARRINGTON, JT
通讯作者：
HARRINGTON, JT