Morphology of luteinizing hormone-releasing hormone neurons as a function of age and hormonal condition in the male rat.
Morphology of luteinizing hormone-releasing hormone neurons as a function of age and hormonal condition in the male rat.
复制标题
雄性大鼠黄体生成素释放激素神经元的形态与年龄和激素状况的函数关系。
DOI：
10.1159/000125138
复制
发表时间：
1989
影响因子：
4.1
通讯作者：
Witkin,JW
中科院分区：
文献类型：
--
作者：
Witkin,JW
许多实验室先前的工作已经表明，促黄体生成激素释放激素（LHRH）神经元显示出从光滑轮廓到极不规则或“多刺”的一系列形状。为了确定这些形状是否反映了性腺类固醇环境或可以被性腺类固醇环境改变，在来自四个实验组的雄性大鼠中检查了LHRH神经元的形态：成年大鼠（2-3个月）;老龄（2 - 3个月）和成年去势（2-3个月，去势4周），有或没有睾酮替代。研究的区域从内侧隔和斜角带的Broca posterously通过外侧视前区和下丘脑前部区域，在整个区域的LHRH神经元的大部分居住的水平延伸。神经元被分成组的基础上的程度不规则的配置文件（“棘手”）。神经元的总数在实验组之间没有差异，并且光滑轮廓的神经元占主导地位。然而，去势动物的LHRH神经元比其他实验组少。在年轻的成年人和老年完整的大鼠和睾酮替代动物的LHRH神经元没有不同的形态。这些结果表明，在雄性大鼠的LHRH神经元往往失去体细胞或树突棘的条件下，性腺类固醇激素显着减少。它也似乎是睾酮水平降低，在老年大鼠与LHRH神经元上的棘状突起的发病率下降不相关。
Previous work in many laboratories has shown that luteinizing hormone-releasing hormone (LHRH) neurons display a range of shapes from smooth-contoured to extremely irregular or‘thorny’ To determine if these forms reflect or can be modified by the gonadal steroid milieu, the morphology of LHRH neurons was examined in male rats from each of four experimental groups: adult (2–3 months); aged (23 months) and adult castrate (2–3 months, castrated for 4 weeks) with or without testosterone replacement. The region studied extended from the level of the medial septum and diagonal band of Broca posteriorly through the lateral preoptic and anterior hypothalamic areas, throughout which region the majority of LHRH neurons reside. Neurons were divided into groups based on the degree of irregularity of their profiles (‘thorniness’). The total numbers of neurons did not differ among the experimental groups and smooth-countoured neurons predominated. However, there were fewer thorny LHRH neurons in the castrate animals than in the other experimental groups. LHRH neurons in the young adult and aged intact rats and testosterone-replaced animals did not differ in their morphology. These results suggest that LHRH neurons in the male rat tend to lose somatic or dendritic spines under conditions in which gonadal steroids are dramatically reduced. It also appears that the levels to which testosterone is reduced in the aged rat are not associated with a decrease in the incidence of spine-like projections on LHRH neurons.