Gamma Knife Radiosurgery for Central Neurocytomas
Gamma Knife Radiosurgery for Central Neurocytomas
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DOI：
10.2176/nmc.50.107
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发表时间：
2010-02-01
影响因子：
1.9
通讯作者：
Fujino, Hideyo
中科院分区：
文献类型：
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作者：
Matsunaga, Shigeo;Shuto, Takashi;Fujino, Hideyo
伽玛刀放射外科治疗中枢神经细胞瘤的长期结果尚不清楚。在本研究中，我们回顾性分析了1997年3月至2007年4月期间接受GKS的7例患者的病历，其中8例为中枢神经细胞瘤。男3例，女4例，年龄9 ~ 53岁，平均32.5岁。GKS时肿瘤体积为0.34-6.10 cm（3）（平均3.86 cm（3））。所有患者在GKS前均接受1 ~ 3次不完全手术切除（平均1.75次），手术标本进行组织学和免疫化学评价。术后随访15 ~ 136个月，平均63.6个月。边缘剂量12-18戈伊，平均13.9戈伊。7例患者中仅1例在GKS术后40个月死于肿瘤复发和颅内出血。其他肿瘤保持无进展。肿瘤生长控制率为7/8。虽然组织学上的恶性转化是罕见的，但这种肿瘤的术后病程并不总是很好，表现为肿瘤进展、颅内出血或颅脊髓播散。因此，我们推荐GKS用于残留或复发肿瘤，特别是在肿瘤进展前的早期检测。
The long-term outcome of gamma knife radiosurgery (GKS) for central neurocytomas remains unclear. In the present study, we retrospectively reviewed the medical records of 7 patients with 8 central neurocytomas who underwent GKS between March 1997 and April 2007. They were 3 men and 4 women age ranging 9 to 53 years old (mean 32.5 years old). The tumor volume at the time of GKS was 0.34-6.10 cm(3) (mean 3.86 cm(3)). All patients had undergone 1 to 3 incomplete surgical resections (mean 1.75) before GKS, the surgical specimen being evaluated histologically and immunohistochemically. The follow-up period after GKS was 15 to 136 months (mean 63.6 months). The tumors were treated with a marginal dose of 12-18 Gy (mean 13.9 Gy). Only one of the seven patients died of tumor recurrence and intracranial hemorrhage 40 months after GKS. The other tumors remained progression-free. The control rate of the tumor growth was 7/8. Although histological malignant transformation is rare, the postoperative course of this tumor is not always good, showing tumor progression, intracranial hemorrhage, or craniospinal dissemination. Therefore, we recommend GKS for residual or recurrent tumors especially at early detection before tumor progression.