ZYGOTICALLY ACTIVE GENES THAT AFFECT THE SPATIAL EXPRESSION OF THE FUSHI-TARAZU SEGMENTATION GENE DURING EARLY DROSOPHILA EMBRYOGENESIS
ZYGOTICALLY ACTIVE GENES THAT AFFECT THE SPATIAL EXPRESSION OF THE FUSHI-TARAZU SEGMENTATION GENE DURING EARLY DROSOPHILA EMBRYOGENESIS
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DOI：
10.1016/0092-8674(86)90543-x
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发表时间：
1986-04-11
期刊：
影响因子：
64.5
通讯作者：
SCOTT, MP
中科院分区：
文献类型：
--
作者：
CARROLL, SB;SCOTT, MP
果蝇体节模式的建立需要三类合子活性基因在发育早期的协调功能。我们研究了这些基因突变对fushi tarazu（ftz）配对规则分割基因空间表达的影响。在四个缺口位点和三个配对规则位点的突变显着影响的初始模式的横向条纹的ftz含核。其他五对规则基因和其他几个位点，影响幼虫表皮模式不影响ftz表达。不能推导出简单的调节关系。相反，ftz基因的表达取决于不同的分割基因之间的相互作用，这些基因活跃在沿着早期胚胎的前后轴沿着的每个位置。
The establishment of the segmental body pattern of Drosophila requires the coordinated functions of three classes of zygotically active genes early in development. We have examined the effects of mutations in these genes on the spatial expression of the fushi tarazu (ftz) pair-rule segmentation gene. Mutations in four gap loci and in three pair-rule loci dramatically affect the initial pattern of transverse stripes of ftz-containing nuclei. Five other pair-rule genes and several other loci that affect the larval cuticular pattern do not detectably affect ftz expression. No simple regulatory relationships can be deduced. Rather, expression of the ftz gene depends upon the interactions among the different segmentation genes active at each position along the anterior-posterior axis of the early embryo.