Malignancy arising in seborrheic keratosis: a report of two cases.
Malignancy arising in seborrheic keratosis: a report of two cases.
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脂溢性角化病引起的恶性肿瘤：两例报告。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
B. Ong
中科院分区：
文献类型：
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作者：
W. Yap;P. H. Tan;B. Ong
我们描述两例恶性转化发生在脂溢性角化病的病理特征。病变累及老年人：一位79岁的中国女士和一位79岁的中国男士，两人均患有长期的脂溢性角化病，近期体积增大。在组织学上，确定的恶性肿瘤分别是浸润性高分化鳞状细胞癌和Bowen病（原位鳞状细胞癌）。存在既存的脂溢性角化病，显示向恶性病灶的过渡区。已提出的病因学因素，以解释这些极其罕见的事件，包括长期的阳光损害和慢性低剂量辐射暴露。
We describe the pathological features of two cases of malignant transformation occurring in seborrheic keratosis. The lesions affected elderly individuals: a 79-year-old Chinese lady and a 79-year-old Chinese gentleman, both of whom had long-standing seborrheic keratoses with recent increase in size. Histologically, the malignancies identified were invasive well-differentiated squamous cell carcinoma and Bowen's disease (squamous carcinoma in situ), respectively. Pre-existing seborrheic keratoses demonstrating a zone of transition into the malignant foci were present. Aetiologic factors that have been proposed to explain these exceedingly rare occurrences have included prolonged sun damage and chronic low dose radiation exposure.