Honeycomb-shaped surface topography induces differentiation of human mesenchymal stem cells (hMSCs): uniform porous polymer scaffolds prepared by the breath figure technique
Honeycomb-shaped surface topography induces differentiation of human mesenchymal stem cells (hMSCs): uniform porous polymer scaffolds prepared by the breath figure technique
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DOI：
10.1039/c3bm60195a
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发表时间：
2014-01-01
影响因子：
6.6
通讯作者：
Shimomura, Masatsugu
中科院分区：
文献类型：
--
作者：
Kawano, Takahito;Sato, Madoka;Shimomura, Masatsugu
为了研究多孔微形貌对 hMSC 分化的影响，通过在潮湿条件下浇铸聚合物溶液成功制备了不同孔径的聚苯乙烯蜂窝支架。我们使用蜂窝支架来实现 hMSC 的微形貌诱导分化。蜂窝支架根据孔的大小引导 hMSC 进行骨特异性和肌特异性分化。这种选择性分化表明，单独的表面微形貌可能对在再生医学和组织工程中使用 hMSC 有效。
Polystyrene honeycomb scaffolds with different pore sizes were successfully fabricated by casting a polymer solution under humid conditions in order to investigate the effect of porous microtopography on hMSC differentiation. We have used honeycomb scaffolds to achieve the microtopography-induced differentiation of hMSCs. Honeycomb scaffolds led hMSCs to osteospecific and myospecific differentiations depending on the size of pores. This selective differentiation suggested that surface microtopography alone may be effective for using hMSCs in regenerative medicine and tissue engineering.