Loss of synaptic vesicles from neuromuscular junctions in aged MRF4-null mice.
Loss of synaptic vesicles from neuromuscular junctions in aged MRF4-null mice.
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DOI：
10.1097/wnr.0b013e328344493c
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发表时间：
2011-03-09
期刊：
影响因子：
1.7
通讯作者：
Kraner SD
中科院分区：
文献类型：
--
作者：
Wang Q;Hebert SL;Rich MM;Kraner SD
MRF4 belongs to the basic helix-loop-helix class of transcription factors and it and other members of its family profoundly influence skeletal muscle development. Less is known about the role of these factors in aging. Since MRF4 is preferentially expressed in sub-synaptic nuclei, we postulated it might play a role in maintenance of the neuromuscular junction. To test this hypothesis, we examined the junctional regions of 19-20 month old mice and found decreased levels of SV2B, a marker of synaptic vesicles, in MRF4-null mice relative to controls. There was a corresponding decrease in grip strength in MRF4-null mice. Taken together, these data suggest that the intrinsic muscle factor MRF4 plays an important role in maintenance of neuromuscular junctions. (117/120 words)
