Treatment with combined intraarterial 5‐FUdR infusion and whole‐liver radiation for colon carcinoma metastatic to the liver Preliminary results
Treatment with combined intraarterial 5‐FUdR infusion and whole‐liver radiation for colon carcinoma metastatic to the liver Preliminary results
复制标题
动脉内5-FUdR输注联合全肝放疗治疗结肠癌肝转移的初步结果
DOI：
10.1097/00000421-198408000-00005
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
T. Sharp
中科院分区：
文献类型：
--
作者：
J. Byfield;R. Barone;Frankel Ss;T. Sharp
28 名结肠癌肝转移患者接受动脉内连续输注 5-氟尿嘧啶脱氧核苷 (5-FUdR) 和周期性全肝放疗 (2000-3000 rad) 治疗。生存期从 25 天到近 4 年不等，并且与开始治疗时肝功能障碍的程度有关。人们经常注意到，在患有轻微影像学异常的患者中建立客观的完全缓解率存在困难。体外和永久植入的动脉输注装置都已被使用，结果有利于内部输注装置。在理想情况下（早期治疗、疾病仅限于肝脏和永久留置泵），预计中位生存期约为 2 年，大量患者在数月至数年内不再出现进展性肝癌。这种方法的剂量限制特点是与肝炎治疗相关，迄今为止已治疗的 28 名患者中有一名被证明是致命的。关于药物和 X 射线引起的肝毒性的起源和减少的临床前研究应具有高度的研究优先权。
TWENTY-EIGHT PATIENTS WITH COLON CARCINOMA metastatic to the liver were treated with continuously infused intra-arterial 5-fluorouracil deoxyriboside (5-FUdR) and cyclical whole-liver radiation (2000–3000 rad). Survivorship ranged from 25 days to almost 4 years and was a clear function of the extent of liver dysfunction at the time of initiation of this treatment. Difficulties in establishing the objective complete response rates in patients with minor imaging abnormalities were frequently noted. Both extracorporeal and permanently implanted arterial infusion devices have been employed, the results favoring the internal infusion units. Under ideal circumstances (early treatment, disease limited to the liver, and a permanent indwelling pump), a median survivorship of approximately 2 years can be projected with a significant number of patients rendered free of progressive cancer in the liver for months to years. The dose-limiting feature of this approach is treatment-related to hepatitis, which proved lethal in one of 28 patients thus far treated. Preclinical studies on the original and reduction of drug- and x-ray-induced liver toxicity should have high research priority.