FUNCTIONAL-ASPECTS OF THE ULTRASTRUCTURE OF TERMINAL BLOOD-VESSELS - A QUANTITATIVE STUDY ON CONSECUTIVE SEGMENTS OF THE FROG MESENTERIC MICROVASCULATURE
FUNCTIONAL-ASPECTS OF THE ULTRASTRUCTURE OF TERMINAL BLOOD-VESSELS - A QUANTITATIVE STUDY ON CONSECUTIVE SEGMENTS OF THE FROG MESENTERIC MICROVASCULATURE
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DOI：
10.1016/0026-2862(82)90028-0
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
FROKJAERJENSEN, J
中科院分区：
文献类型：
--
作者：
BUNDGAARD, M;FROKJAERJENSEN, J
本文观察了蛙肠系膜微血管连续段的超微结构。根据微血管床的流动模式，将微血管床分为小动脉、动脉毛细血管、中毛细血管、静脉毛细血管、微静脉和通道。研究中包括每个节段的随机抽样横截面。使用体视学原理，一些结构参数进行了量化;血管直径;内皮尺寸;周细胞覆盖;直径，分布和体积密度的内皮细胞，质膜囊泡;长度/单位面积和深度的内皮细胞间裂隙;频率的transendothelial通道和窗;和体积密度的线粒体在内皮细胞质中。形态测量结果显示整个微血管系统的结构逐渐变化。青蛙肠系膜微血管和哺乳动物骨骼肌的微血管之间的广泛的结构相似性被证明，表明青蛙肠系膜毛细血管是一个有用的模型哺乳动物连续毛细血管一般。通过将目前的形态测定结果与最近对单个青蛙肠系膜毛细血管渗透性的实验测定相关联，估计了囊泡和裂隙在经毛细血管转运中的相对重要性（Crone等人，1978）。内皮间隙是小分子亲水性溶质的主要通道。
The ultrastructure of consecutive segments of the frog mesenteric microvessels was examined. The microvascular beds were subdivided into arterioles, arterial capillaries, midcapillaries, venous capillaries, venules and thoroughfare channels on the basis of the flow pattern. Randomly sampled cross sections of each segment were included in the study. Using stereological principles, a number of structural parameters were quantified; vascular diameters; endothelial dimensions; pericyte coverage; diameters, distribution and volume density of endothelial, plasmalemmal vesicles; length/unit area and depth of the interendothelial clefts; frequency of transendothelial channels and fenestrae; and volume density of mitochondria in the endothelial cytoplasm. The morphometric results showed gradual structural variations throughout the microvasculature. Extensive structural similarities between microvessels of the frog mesentery and those of mammalian skeletal muscles were demonstrated, indicating that frog mesenteric capillaries are a useful model of mammalian continuous capillaries in general. An estimate of the relative importance in transcapillary transport of the vesicles and cleft was made by correlating the present morphometric findings with recent experimental determination of permeability on single frog mesenteric capillaries (Crone et al, 1978). The interendothelial cleft is the main pathway for small hydrophilic solutes.