Dynamic Patterns of Parasitism and Immunity across Host Development Influence Optimal Strategies of Resource Allocation
Dynamic Patterns of Parasitism and Immunity across Host Development Influence Optimal Strategies of Resource Allocation
复制标题
宿主发育过程中寄生和免疫的动态模式影响资源分配的最佳策略
DOI：
10.1086/682705
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
A. Graham
中科院分区：
文献类型：
--
作者：
A. Tate;A. Graham
将生理机制整合到生活史理论中，是我们理解生活史进化的制约和驱动因素的一个新兴前沿。幼虫发育途径和免疫途径之间对抗的动态模式说明了在面临权衡的情况下确定生活史策略最优的机制的重要性。例如，当发育过程短暂地优先于资源或途径结构时，就会发生发育干扰，阻止分配给免疫力或其他特征。我们设计了一个感染幼虫发育的宿主内模型，以探索发育动态对最优资源动员和分配策略以及对幼虫抗性和耐受性表型的影响。该模型将机制激发的发育干扰功能形式与对攻击特定幼虫阶段的寄生虫的免疫结合在一起。我们发现，发育干扰通常增加了对结构性免疫的最优投资，降低了最优资源调集率，但结果对首次感染时的发育阶段很敏感。此外，发育干预降低了抵抗力，但通常会提高对感染的耐受性。我们展示了这些动力学对寄主易感性的经验估计的潜在影响，并讨论了将现实的生理机制和发育动力学纳入昆虫和其他生物的生活史理论的一般含义。
The integration of physiological mechanisms into life-history theory is an emerging frontier in our understanding of the constraints and drivers of life-history evolution. Dynamic patterns of antagonism between developmental and immunological pathways in juvenile insects illustrate the importance of mechanisms for determining life-history strategy optima in the face of trade-offs. For example, developmental interference occurs when developmental processes transiently take priority over resources or pathway architecture, preventing allocation to immunity or other traits. We designed a within-host model of infected larval development to explore the impact of developmental dynamics on optimal resource mobilization and allocation strategies as well as on larval resistance and tolerance phenotypes. The model incorporates mechanism-inspired functional forms of developmental interference with immunity against parasites that attack specific larval stages. We find that developmental interference generally increases optimal investment in constitutive immunity and decreases optimal resource mobilization rates, but the results are sensitive to the developmental stage at first infection. Moreover, developmental interference reduces resistance but generally increases tolerance of infection. We demonstrate the potential impact of these dynamics on empirical estimates of host susceptibility and discuss the general implications of incorporating realistic physiological mechanisms and developmental dynamics for life-history theory in insects and other organisms.
影响因子：
23.8
作者：
Arrese EL;Soulages JL
通讯作者：
Soulages JL