Myocarditis Associated with Influenza A H1N1pdm2009.
Myocarditis Associated with Influenza A H1N1pdm2009.
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DOI：
10.1155/2012/351979
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kanzaki Y
中科院分区：
文献类型：
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作者：
Ukimura A;Satomi H;Ooi Y;Kanzaki Y
急性心肌炎是流感感染的常见并发症。流感感染累及心肌的频率差异很大，临床严重程度从无症状到暴发性变化不等。最严重的情况可能会导致死亡，因为心脏功能受损，尽管这种与流感感染相关的暴发性心肌炎是罕见的，正如以前的论文所表明的那样。在2009年流感大流行之后，我们报道了日本15名2009年甲型H1N1pdm型心肌炎患者的临床特征。在我们随后对2009年H1N1pdm2009相关心肌炎病例报告或系列患者的文献调查中，我们确定了58例详细病例。我们在这里讨论暴发性心肌炎的高患病率(36/58，62%)在报告的与H1N1pdm2009相关的心肌炎患者中。17例暴发性心肌炎患者需要机械循环支持，其中13例痊愈。我们强调需要提高对流感相关性心肌炎的认识；这些知识将有助于在未来流感大流行期间及早诊断和治疗这一致命并发症。
Acute myocarditis is a well-known complication of influenza infection. The frequency of myocardial involvement in influenza infection varies widely, with the clinical severity ranging from asymptomatic to fulminant varieties. The worst cases can result in death due to impaired cardiac function, although such fulminant myocarditis associated with influenza infection is rare, as shown by previous papers. Following the 2009 influenza pandemic, we reported on the clinical features of a cohort of 15 patients in Japan with H1N1pdm2009 myocarditis. In our subsequent survey of the literature for case reports or series of patients with myocarditis associated with H1N1pdm2009, we identified 58 detailed cases. We discuss here the high prevalence of fulminant myocarditis (36/58, 62%) among patients reported to have myocarditis associated with H1N1pdm2009. Mechanical circulatory support was required in 17 of the patients with fulminant myocarditis, 13 of whom recovered. We stress the need for increased awareness of influenza-associated myocarditis; such knowledge will facilitate earlier diagnosis and treatment of this fatal complication during future influenza pandemics.