Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire
Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire
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DOI：
10.1080/00365520510012208
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发表时间：
2005-05-01
影响因子：
1.9
通讯作者：
Chassany, O
中科院分区：
文献类型：
--
作者：
Marquis, P;De la Loge, C;Chassany, O
目标。慢性便秘的特点是排便困难、不频繁或似乎不完全。制定患者便秘生活质量评估（PAC-QOL）问卷是为了满足对一种标准化的、患者报告的结果测量方法的需求，以评估便秘随时间的变化。材料和方法。PAC-QOL的条目来自文献、临床专家和患者。通过主成分分析和多特征分析，保留了28个条目，形成了4个子量表（忧虑和关注、身体不适、心理不适和满意度）和一个总体量表。在美国、欧洲、加拿大和澳大利亚进行了验证研究，以评估PAC-QOL量表的内部一致性信度（Cronbach’s alpha）、可重复性（类内相关系数（ICCs））、有效性（方差模型分析）和响应性（效应大小）。结果。PAC-QOL量表具有内部一致性（Cronbach's alpha > = 0.80）和可重复性（ICCs > = 0.70，除了满意度分量表ICC = 0.66）。PAC-QOL评分与腹痛（p< 0.001）和便秘严重程度（p< 0.05）显著相关。报告便秘改善的患者在6周内的效应大小从中等到较大，亚量表效应大小范围为0.76至3.41，总体量表效应大小= 1.77。在欧洲、加拿大和澳大利亚进行的验证研究中也观察到类似的结果。结论。PAC-QOL是一个简短但全面的评估便秘对患者日常功能和健康的负担。多国研究表明，PAC-QOL在内部是一致的、可重复的、有效的，并且随着时间的推移而不断改进。
Objective. Chronic constipation is characterized by difficult, infrequent, or seemingly incomplete bowel movements. The Patient Assessment of Constipation Quality of Life (PAC-QOL) questionnaire was developed to address the need for a standardized, patient-reported outcomes measure to evaluate constipation over time. Material and methods. Items for the PAC-QOL were generated from the literature, clinical experts, and patients. Following principal components and multitrait analyses, 28 items were retained forming four subscales ( worries and concerns, physical discomfort, psychosocial discomfort, and satisfaction) and an overall scale. Validation studies were conducted in the United States, Europe, Canada, and Australia, to evaluate the internal consistency reliability ( Cronbach's alpha), reproducibility ( Intraclass Correlation Coefficients (ICCs)), validity ( analysis of variance models), and responsiveness ( effect size) of the PAC-QOL scales. Results. The PAC-QOL scales were internally consistent ( Cronbach's alpha > 0.80) and reproducible ( ICCs > 0.70, except for the satisfaction subscale ICC = 0.66). PAC-QOL scale scores were significantly associated with abdominal pain ( p< 0.001) and constipation severity ( p< 0.05). Effect sizes in patients reporting improvements in constipation over a 6-week period were moderate to large, with subscale effect sizes ranging from 0.76 to 3.41 and the overall scale effect size = 1.77. Similar findings were observed in validation studies conducted in Europe, Canada, and Australia. Conclusions. The PAC-QOL is a brief but comprehensive assessment of the burden of constipation on patients' everyday functioning and well-being. Multinational studies demonstrate that the PAC-QOL is internally consistent, reproducible, valid, and responsive to improvements over time.