Mesoporous silica nanoparticles in target drug delivery system: A review.
Mesoporous silica nanoparticles in target drug delivery system: A review.
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DOI：
10.4103/2230-973x.160844
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发表时间：
2015-07
影响因子：
0.5
通讯作者：
Gulati N
中科院分区：
文献类型：
--
作者：
Bharti C;Nagaich U;Pal AK;Gulati N
由于药物分子缺乏特异性和溶解性，患者不得不服用高剂量的药物以达到治疗疾病的预期治疗效果。为了解决这些问题，在药物中存在各种药物载体，其可用于将治疗剂递送到体内的靶位点。介孔氧化硅材料是一种可以克服上述问题并以可控和可持续的方式产生效果的有希望的候选材料。特别地，介孔二氧化硅纳米颗粒（MSNs）被广泛用作递送试剂，因为二氧化硅具有有利的化学性质、热稳定性和生物相容性。二氧化硅独特的介孔结构有利于药物的有效负载及其随后的靶位控释。介孔的性质，包括孔径、高载药量和孔隙率以及表面性质，可以根据用于制备MSN的添加剂而改变。活性表面使功能化能够改变表面性质并连接治疗分子。它们广泛用于诊断、靶向药物递送、生物传感、细胞摄取等领域，在生物医学领域。本文综述了含二氧化硅介孔纳米粒子的研究进展及其在生物医学领域的应用。
Due to lack of specification and solubility of drug molecules, patients have to take high doses of the drug to achieve the desired therapeutic effects for the treatment of diseases. To solve these problems, there are various drug carriers present in the pharmaceuticals, which can used to deliver therapeutic agents to the target site in the body. Mesoporous silica materials become known as a promising candidate that can overcome above problems and produce effects in a controllable and sustainable manner. In particular, mesoporous silica nanoparticles (MSNs) are widely used as a delivery reagent because silica possesses favorable chemical properties, thermal stability, and biocompatibility. The unique mesoporous structure of silica facilitates effective loading of drugs and their subsequent controlled release of the target site. The properties of mesoporous, including pore size, high drug loading, and porosity as well as the surface properties, can be altered depending on additives used to prepare MSNs. Active surface enables functionalization to changed surface properties and link therapeutic molecules. They are used as widely in the field of diagnosis, target drug delivery, bio-sensing, cellular uptake, etc., in the bio-medical field. This review aims to present the state of knowledge of silica containing mesoporous nanoparticles and specific application in various biomedical fields.