The interaction between the complement system and hemostatic factors.
The interaction between the complement system and hemostatic factors.
复制标题
DOI：
10.1097/moh.0000000000000605
复制
发表时间：
2020-09
影响因子：
3.2
通讯作者：
Afshar-Kharghan V
中科院分区：
文献类型：
--
作者：
Oncul S;Afshar-Kharghan V
探讨补体系统与止血因子(凝血级联、血小板、血管内皮细胞和血管性血友病因子)之间的串扰，以及这种相互作用在生理和病理条件下的后果。补体和凝血系统由丝氨酸蛋白酶组成，在基因上是相关的。除了共同的祖先基因外，补体系统和止血系统通过蛋白质-蛋白质相互作用直接相互作用，并间接在血小板和内皮细胞表面相互作用。补体系统与止血因子之间的密切相互作用体现在生理和病理条件下，如对血栓形成的炎症反应、炎症区域的血栓形成以及补体疾病的血栓性并发症。补体系统和止血之间的相互作用对于体内平衡和宿主对组织损伤的保护性反应至关重要，但也导致了一些血栓性和炎症性疾病的发病。
To discuss the crosstalk between the complement system and hemostatic factors (coagulation cascade, platelet, endothelium, and Von Willebrand Factor), and the consequences of this interaction under physiologic and pathologic conditions. The complement and coagulation systems are comprised of serine proteases and are genetically related. In addition to the common ancestral genes, the complement system and hemostasis interact directly, through protein-protein interactions, and indirectly, on the surface of platelets and endothelial cells. The close interaction between the complement system and hemostatic factors is manifested both in physiologic and pathologic conditions, such as in the inflammatory response to thrombosis, thrombosis at the inflamed area, and thrombotic complications of complement disorders. The interaction between the complement system and hemostasis is vital for homeostasis and the protective response of the host to tissue injury, but also results in the pathogenesis of several thrombotic and inflammatory disorders.