CONFORMATION OF UN-COMPLEXED NATURAL ANTAMANIDE CRYSTALLIZED FROM CH3CN-H2O
CONFORMATION OF UN-COMPLEXED NATURAL ANTAMANIDE CRYSTALLIZED FROM CH3CN-H2O
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DOI：
10.1073/pnas.76.4.1532
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发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
OTTENHEYM, HCJ
中科院分区：
文献类型：
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作者：
KARLE, IL;WIELAND, T;OTTENHEYM, HCJ
天然的安他曼胺是一种环十肽，来自于假凤头伞，已被证明与具有生物活性的合成[Phe4， Val6]安他曼胺具有相同的主链构象和类似的侧基。这两种化合物在晶体中的排列方式大不相同。在[Phe4， Val6]安他胺晶体中形成了具有极性衬里的大通道，而在天然安他胺晶体中，晶体中的大通道完全被亲脂性基团Pro， Phe和Ala残基包围。安他胺C64H78N10O10·8H2O·X在空间群p212121a = 15.88 Å，b= 34.88 Å， c= 13.61 Å中结晶。
Natural antamanide, a cyclic decapeptide fromAmanita phalloides, has been shown to have the same conformation for the backbone and comparable side groups as the biologically active synthetic [Phe4, Val6]antamanide. Packing in the crystal is quite different for the two compounds. Large channels with a polar lining are formed in the crystals of [Phe4, Val6]antamanide, whereas in natural antamanide large channels in the crystal are completely surrounded by the lipophilic side groups of the Pro, Phe, and Ala residues. Antamanide, C64H78N10O10·8H2O·X, crystallizes in space group P212121witha= 15.88 Å,b= 34.88 Å, andc= 13.61 Å.