Changes in Event-Related Desynchronization and Synchronization during the Auditory Oddball Task in Schizophrenia Patients.
Changes in Event-Related Desynchronization and Synchronization during the Auditory Oddball Task in Schizophrenia Patients.
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DOI：
10.2174/1874440001206010026
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Tamura T
中科院分区：
文献类型：
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作者：
Fujimoto T;Okumura E;Takeuchi K;Kodabashi A;Tanaka H;Otsubo T;Nakamura K;Sekine M;Kamiya S;Higashi Y;Tsuji M;Shimooki S;Tamura T
我们使用脑磁图（MEG）和脑电图（EEG）研究了精神分裂症患者和正常受试者在听觉oddball任务期间大脑皮层振荡的时空动力学差异。研究了10例右利手男性精神分裂症患者。我们使用了一种新开发的自适应空间滤波算法，该算法针对MEG和EEG数据的鲁棒源时间-频率重建进行了优化，并在theta、低α（8-10 Hz）、高α（10-13 Hz）和β波段的事件相关去极化（ERD）和同步（ERS）功能图中获得了连续图像。患者在750-1000 ms时的β ERD功率在右上颞和顶叶大区域以及双侧背额和背内侧顶叶区域的小上部显著增加。与对照组相比，精神分裂症患者在oddball任务期间，在250-500 ms时左颞极的Theta ERS功率显著增加，在500-750 ms时两半球的前扣带回皮质的背侧、内侧额叶和前部以及外侧颞区的左侧部分显著增加（家族错误校正p<0.05）。在500-750 ms时，右枕区的较低α ERS功率显著降低，在750-1000 ms时，右中线顶骨和双侧枕区的较低α ERS功率显著降低。在750-1000 ms时，右中线顶骨和左枕区的较高α ERS功率显著降低。在θ ERS的左颞极、中线额叶和前扣带皮层，α ERS的枕叶，β ERD的右颞-额-顶、中线额叶和前扣带皮层中观察到ERS变化。这些发现可能反映了活跃的大神经元群之间的相互作用以及它们彼此之间的通信的障碍，这可能与异常的认知和精神病理功能有关。 MEG时频分析对ERD和ERS的研究有助于阐明精神分裂症患者的信息加工功能障碍。
We studied differences in the spatiotemporal dynamics of cortical oscillation across brain regions of patients with schizophrenia and normal subjects during the auditory oddball task using magnetoencephalography (MEG) and electroencephalography (EEG). Ten right-handed male schizophrenia patients were studied. We used a newly developed adaptive spatial filtering algorithm optimized for robust source time-frequency reconstruction of MEG and EEG data, and obtained consecutive images in functional maps of event-related desynchronization (ERD) and synchronization (ERS) in theta, lower alpha (8–10 Hz), upper alpha (10–13 Hz), and beta bands. Beta ERD power at 750–1000 ms in patients was significantly increased in large right upper temporal and parietal regions and small upper portions of bilateral dorsal frontal and dorsal-medial parietal regions. Theta ERS power in schizophrenic patients during the oddball task was significantly increased in the left temporal pole at 250–500 ms, and was significantly increased in dorsal, medial frontal, and anterior portions of the anterior cingulate cortex in both hemispheres, and the left portion of lateral temporal regions at 500–750 ms, compared to the control group (family-wise error correction p<0.05). Lower alpha ERS power was significantly decreased in the right occipital region at 500–750 ms and in the right midline parietal and bilateral occipital regions at 750–1000 ms. Upper alpha ERS power was significantly decreased in right midline parietal and left occipital regions at 750–1000 ms. ERD/ERS changes were noted in the left temporal pole and midline frontal and anterior cingulate cortex in theta ERS, occipital lobe in alpha ERS, and right temporal-frontal-parietal, midline frontal, and anterior cingulate cortex in beta ERD. These findings may reflect disturbances in interaction among active large neuronal groups and their communication with each other that may be related to abnormal cognitive and psychopathological function. Study of ERD and ERS by time-frequency analyses using MEG is useful to clarify data processing dysfunction in schizophrenia.