Integrative and Conjugative Elements (ICEs): What They Do and How They Work.
Integrative and Conjugative Elements (ICEs): What They Do and How They Work.
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DOI：
10.1146/annurev-genet-112414-055018
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发表时间：
2015
影响因子：
11.1
通讯作者：
Grossman AD
中科院分区：
文献类型：
--
作者：
Johnson CM;Grossman AD
水平基因转移在微生物进化中起着重要作用，允许微生物获得新的基因和表型。积分和共轭元素（ICE，a.k.a.接合转座子）是整合到宿主基因组中的模块化移动的遗传元件，并且在染色体复制和细胞分裂期间被动繁殖。ICE基因表达的诱导导致切除、保守缀合机制（IV型分泌系统）的产生以及将DNA转移至适当受体的潜力。ICE通常含有通常与ICE生命周期无关并赋予宿主细胞表型的货物基因。我们总结了ICE的生命周期和发现，一些监管机制，以及货物类型如何影响我们对ICE的看法。我们讨论了ICE如何获得新的货物基因，并描述了该领域的挑战和ICE生物学的各种观点。
Horizontal gene transfer plays a major role in microbial evolution, allowing microbes to acquire new genes and phenotypes. Integrative and conjugative elements (ICEs, a.k.a. conjugative transposons) are modular mobile genetic elements integrated into a host genome and are passively propagated during chromosomal replication and cell division. Induction of ICE gene expression leads to excision, production of the conserved conjugation machinery (a type IV secretion system), and the potential to transfer DNA to appropriate recipients. ICEs typically contain cargo genes that are not usually related to the ICE life cycle and that confer phenotypes to host cells. We summarize the life cycle and discovery of ICEs, some of the regulatory mechanisms, and how the types of cargo have influenced our view of ICEs. We discuss how ICEs can acquire new cargo genes and describe challenges to the field and various perspectives on ICE biology.
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影响因子：
64.8
作者：
Beaber, JW;Hochhut, B;Waldor, MK
通讯作者：
Waldor, MK
影响因子：
3.2
作者：
Beaber, JW;Hochhut, B;Waldor, MK
通讯作者：
Waldor, MK
影响因子：
3.2
作者：
Böltner, D;MacMahon, C;Osborn, AM
通讯作者：
Osborn, AM
影响因子：
11.4
作者：
Bouvier, M;Demarre, G;Mazel, D
通讯作者：
Mazel, D
影响因子：
3.2
作者：
Burrus, V;Waldor, MK
通讯作者：
Waldor, MK