A segmentation protocol and MRI atlas of the C57BL/6J mouse neocortex
A segmentation protocol and MRI atlas of the C57BL/6J mouse neocortex
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DOI：
10.1016/j.neuroimage.2013.04.008
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发表时间：
2013-09-01
期刊：
影响因子：
5.7
通讯作者：
Reutens, David C.
中科院分区：
文献类型：
--
作者：
Ullmann, Jeremy F. P.;Watson, Charles;Reutens, David C.
新皮层是哺乳动物大脑皮层的最大组成部分。它将感官输入与经验和记忆相结合，对生物体的内部和外部环境产生复杂的反应。虽然已经使用组织学技术绘制了小鼠新皮层的区域图案，但在磁共振图像中尚未全面分割新皮层。本研究提出了一种对C57 BL/6 J小鼠新皮层进行系统分割的方法。我们创建了一个最小变形图谱，它被分层分割成74个新皮层和皮层相关区域，使其成为目前可用的小鼠新皮层最详细的图谱。此外，我们还提供了每个结构的平均体积和相对强度，以及两个最常引用的小鼠大脑组织学图谱之间的命名比较。这个MR图谱可供下载，它应该使研究人员能够在皮质疾病的遗传模型中进行自动分割。(C)2013 Elsevier Inc. All rights reserved.
The neocortex is the largest component of the mammalian cerebral cortex. It integrates sensory inputs with experiences and memory to produce sophisticated responses to an organism's internal and external environment. While areal patterning of the mouse neocortex has been mapped using histological techniques, the neocortex has not been comprehensively segmented in magnetic resonance images. This study presents a method for systematic segmentation of the C57BL/6J mouse neocortex. We created a minimum deformation atlas, which was hierarchically segmented into 74 neocortical and cortical-related regions, making it the most detailed atlas of the mouse neocortex currently available. In addition, we provide mean volumes and relative intensities for each structure as well as a nomenclature comparison between the two most cited histological atlases of the mouse brain. This MR atlas is available for download, and it should enable researchers to perform automated segmentation in genetic models of cortical disorders. (C) 2013 Elsevier Inc. All rights reserved.