Expression of TGF-βs and TGF-β type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus
Expression of TGF-βs and TGF-β type II receptor in cerebrospinal fluid of patients with idiopathic normal pressure hydrocephalus
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DOI：
10.1016/j.neulet.2006.11.039
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发表时间：
2007-02-14
影响因子：
2.5
通讯作者：
Arai, Hajime
中科院分区：
文献类型：
--
作者：
Li, Xianfeng;Miyajima, Masakazu;Arai, Hajime
我们研究了 21 名特发性正常压力脑积水 (INPH) 患者和 14 名无神经系统疾病对照患者的脑脊液 (CSF) 样本。使用 ELISA 测量脑脊液中富含亮氨酸的 α-2-糖蛋白 (LRG)、转化生长因子 (TGF)-β 1、2、3 和 TGF-β II 型受体 (T beta R-II) 的浓度。 INPH患者脑脊液中TGF-βI、TβR-II和LRG的水平显着高于对照组，而TGF-β2水平在INPH患者和对照组之间没有发现显着差异。本研究表明，INPH 患者中 TGF-β 的表达可能受到不同的调节。这些结果还表明，脑脊液中TGF-β1、TβR-II和LRG水平测定对于INPH患者的诊断有用，TGF-β1、TβR-II和LRG可能参与了该病的发病机制。 (c) 2006 年，爱思唯尔爱尔兰有限公司出版。
We investigated cerebrospinal fluid (CSF) samples from 21 patients with idiopathic normal pressure hydrocephalus (INPH) and 14 controls without neurological disease. The concentrations of leucine-rich alpha-2-alycoprotein (LRG), transforming growth factor (TGF)-beta 1, 2, 3 and TGF-beta type II receptor (T beta R-II) in CSF were measured using ELISA. TGF-beta I, T beta R-II and LRG CSF levels of patients with INPH were significantly higher than controls, whereas no significant differences in TGF-beta 2 levels were found between INPH patients and controls. The present study suggests that TGF-beta s expressions may be modulated differently in patients with INPH. These results also indicate that the CSF level assay of TGF-beta 1. T beta R-II and LRG is useful for the diagnosis of patients with INPH, and TGF-beta 1, T beta R-II and LRG may be involved in the pathogenesis of the disease. (c) 2006 Published by Elsevier Ireland Ltd.