Copper(I)-Catalyzed Diastereoselective Borylative Exo-Cyclization of Alkenyl Aryl Ketones
Copper(I)-Catalyzed Diastereoselective Borylative Exo-Cyclization of Alkenyl Aryl Ketones
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DOI：
10.1055/s-0035-1560721
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发表时间：
2015-11
期刊：
影响因子：
2
通讯作者：
E. Yamamoto;R. Kojima;K. Kubota;Hajime Ito
中科院分区：
文献类型：
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作者：
E. Yamamoto;R. Kojima;K. Kubota;Hajime Ito
摘要报道了在铜催化下烯基酮与二硼频哪醇酯的非对映选择性硼化外环化反应。烯基芳基酮在CuCl/Xantphos催化剂体系下的反应以良好的产率和高的顺式选择性提供了四元或五元环顺式-2-（硼基甲基）环烷醇衍生物。该方法的实用性证明了进一步的转换的环状产品。
Abstract Copper(I)-catalyzed diastereoselective borylative exo-cyclization of alkenyl ketones with bis(pinacolato)diboron is reported. The reaction of alkenyl aryl ketones under a CuCl/Xantphos catalyst system provides four- or five-membered-ring syn-2-(borylmethyl)cycloalkanol derivatives in good yields with high syn selectivities. The utility of this method is demonstrated by further transformations of the cyclic products.