Prolonged Orocecal Transit Time Enhances Serum Bile Acids Through Bacterial Overgrowth, Contributing Factor to Gallstone Disease
Prolonged Orocecal Transit Time Enhances Serum Bile Acids Through Bacterial Overgrowth, Contributing Factor to Gallstone Disease
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DOI：
10.1097/mcg.0b013e3182a14fba
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发表时间：
2014-04-01
影响因子：
2.9
通讯作者：
Dhawan, Devinder K.
中科院分区：
文献类型：
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作者：
Kaur, Jaspreet;Rana, Satya V.;Dhawan, Devinder K.
背景：胆结石（GS）与肠道转运缓慢有关，但转运时间改变对GS患者胃肠道生理变化的影响尚不清楚。目的：探讨胆石病与肠蠕动改变的关系，以及肠蠕动如何改变血清胆汁酸（SBA）水平。研究：共纳入333名受试者，其中183名为GS患者，150名年龄和性别匹配的对照组。通过测量口腔运输时间（OCTT）来评估肠道运输时间。呼气试验用于评估OCTT和小肠细菌过度生长（SIBO）。用酶比色法测定总SBA水平。线性回归分析OCTT与SBA水平之间的相互关系。结果：口腔过境时间明显延迟(P
Background: Gallstones (GS) are associated with slow intestinal transit but the effect of altered transit time on physiological changes in gastrointestinal tract among GS patients is poorly understood.Goals: To investigate the association of gallstone disease with change in intestinal motility and how motility alters serum bile acid(SBA) levels.Study: A total of 333 subjects were enrolled, of which 183 were GS patients and 150 age-matched and sex-matched controls. Intestinal transit time was assessed by measuring orocecal transit time(OCTT). Breath tests were used to evaluate OCTT and small intestinal bacterial overgrowth (SIBO). Total SBA levels were measured by enzymatic colorimetric assay. A linear regression analysis was performed to look for interrelationship between OCTT and SBA levels.Results: Orocecal transit time was significantly delayed (P