Potentiation of DOM-induced stimulus control by fluoxetine and citalopram: role of pharmacokinetics.
Potentiation of DOM-induced stimulus control by fluoxetine and citalopram: role of pharmacokinetics.
复制标题
氟西汀和西酞普兰增强 DOM 诱导的刺激控制：药代动力学的作用。
DOI：
10.1016/s0024-3205(02)01861-1
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发表时间：
2002
期刊：
影响因子：
6.1
通讯作者：
Winter,JC
中科院分区：
文献类型：
--
作者：
Eckler,JR;Doat,MM;Rabin,RA;Winter,JC
本研究探讨了2，5-二甲氧基-4-甲基苯丙胺[DOM]和选择性5-羟色胺再摄取抑制剂[SSRI]西酞普兰在大鼠训练DOM [0.6 mg/kg; 75 min预处理时间]作为一个区别刺激之间的相互作用。以1.0 mg/kg剂量的西酞普兰预处理使DOM剂量反应关系向左移动。与以前测试的SSRI的，DOM诱导的刺激控制的增强发生在没有显着的部分取代西酞普兰。在存在和不存在西酞普兰和氟西汀的情况下，使用GC-MS方法测量DOM脑水平，以评价药代动力学对观察到的行为效应的贡献。数据表明，氟西汀而不是西酞普兰显着增加DOM脑水平。它的结论是，DOM作为一个歧视性刺激的影响是加强西酞普兰的急性给药，这种效果是不介导的相加或药代动力学机制。
The present investigation examined the interaction between 2,5-dimethoxy-4-methylamphetamine [DOM] and the selective serotonin reuptake inhibitor [SSRI] citalopram in rats trained with DOM [0.6 mg/kg; 75 min pretreatment time] as a discriminative stimulus. Pretreatment with citalopram at a dose of 1.0 mg/kg shifted the DOM dose response relationship to the left. Unlike previously tested SSRI's, the enhancement of DOM-induced stimulus control occurred in the absence of significant partial substitution by citalopram. DOM brain levels were measured using a GC-MS method both in the presence and absence of citalopram and fluoxetine in order to evaluate the pharmacokinetic contribution to the observed behavioral effect. The data indicated that fluoxetine but not citalopram significantly increased DOM brain levels. It is concluded that the effects of DOM as a discriminative stimulus are potentiated by the acute administration of citalopram and this effect is not mediated by additivity or pharmacokinetic mechanisms.