Effect of Cytotoxic Agents on Antibody Production
Effect of Cytotoxic Agents on Antibody Production
复制标题
细胞毒剂对抗体产生的影响
作者：
M. Berenbaum
人们早就知道抗体的产生可能会受到某些细胞毒剂的抑制，例如 X 辐射、苯和芥子气1。最近，据报道具有这种作用的药物数量已扩大到包括可的松2、氮芥3、秋水仙碱4、脱氧吡哆醇5、8-氮鸟嘌呤6、各种致癌物7、β-3-噻吩基丙氨酸8、6-巯基嘌呤9和氨甲蝶呤10。其中许多是有效的抗肿瘤化合物。
IT has long been known that antibody-production may be inhibited by certain cytotoxic agents, for example, X-radiation, benzene and mustard gas1. More recently, the number of agents reported to have this effect has been extended to include cortisone2, nitrogen mustards3, colchicine4, deoxypyridoxine5, 8-azaguanine6, various carcinogens7, β-3-thienylalanine8, 6-mercaptopurine9 and amethopterin10. Many of these are potent anti-tumour compounds.