Association of 2184AG Polymorphism in the RAGE Gene with Diabetic Nephropathy in Chinese Patients with Type 2 Diabetes.
Association of 2184AG Polymorphism in the RAGE Gene with Diabetic Nephropathy in Chinese Patients with Type 2 Diabetes.
复制标题
RAGE基因2184AG多态性与中国2型糖尿病患者糖尿病肾病的相关性
DOI：
10.1155/2015/310237
复制
发表时间：
2015
影响因子：
4.3
通讯作者：
Liu JY
中科院分区：
文献类型：
--
作者：
Cai W;Li J;Xu JX;Liu Y;Zhang W;Xiao JR;Zhu LY;Liu JY
目标。晚期糖基化终产物及其细胞受体(RAGE)之间的相互作用在糖尿病微血管并发症的发病机制中起着重要作用。本研究旨在探讨RAGE基因2184A/G多态性与中国汉族人2型糖尿病肾病的关系。方法：研究方法。本研究共纳入868例2型糖尿病患者(486例无糖尿病肾病和382例有糖尿病肾病)。采用聚合酶链式反应-限制性片段长度多态方法检测2184A/G多态的基因频率和等位基因频率。结果。糖尿病肾病组G等位基因和AG+GG等位基因频率显著低于无糖尿病肾病组(P=0.001和P=0.005)。在调整可能的混杂因素后，多因素Logistic回归分析显示2184A/G基因多态性与糖尿病肾病独立相关(OR=0.46，95%CI：0.22~0.92，P=0.028)。结论。我们的研究表明RAGE基因2184A/G多态性与中国汉族2型糖尿病患者的糖尿病肾病显著相关。
Objective. The interaction between advanced glycation end products and their cellular receptor (RAGE) has an important role in the pathogenesis of diabetic microvascular complications. The aim of this study was to investigate the relationship between the 2184A/G polymorphism in the RAGE gene and diabetic nephropathy in Chinese Han patients with type 2 diabetes mellitus. Methods. A total of 868 patients with type 2 diabetes mellitus (486 without and 382 with diabetic nephropathy) were enrolled in this study. The genotype and allele frequencies of the 2184A/G polymorphism were detected using the polymerase chain reaction-restriction fragment-length polymorphism method. Results. The G allele and AG + GG genotype frequencies in patients with diabetic nephropathy were significantly lower than those in patients without diabetic nephropathy (P = 0.001 and P = 0.005, resp.). After adjustments for possible confounders, multivariate logistic regression analyses showed that the 2184A/G polymorphism was independently associated with diabetic nephropathy (OR = 0.46, 95% CI: 0.22–0.92, P = 0.028). Conclusions. Our study indicated that the 2184A/G polymorphism in the RAGE gene was significantly associated with diabetic nephropathy in Chinese Han patients with type 2 diabetes.