Statin therapy and levels of hemostatic factors in a healthy population: the Multi-Ethnic Study of Atherosclerosis
Statin therapy and levels of hemostatic factors in a healthy population: the Multi-Ethnic Study of Atherosclerosis
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DOI：
10.1111/jth.12223
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发表时间：
2013-06-01
影响因子：
10.4
通讯作者：
Cushman, M.
中科院分区：
文献类型：
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作者：
Adams, N. B.;Lutsey, P. L.;Cushman, M.
背景HMG-CoA还原酶抑制剂（他汀类药物）可降低健康人群静脉血栓栓塞（VTE）的风险。他汀类药物降低炎症生物标志物的水平;目的在一个健康人群的大队列中，我们研究了他汀类药物使用与VTE风险相关的血浆止血因子的关联。方法在动脉粥样硬化的多种族研究（梅萨）中进行了横断面分析，该队列研究包括6814名年龄在45- 84岁的健康男性和女性，基线时无临床心血管疾病; 1001例基线时使用他汀类药物。排除了23名华法林使用者。在他汀类药物使用者和非使用者之间比较年龄、种族和性别校正的平均止血因子水平，并使用多变量线性回归模型评估他汀类药物使用与止血因子的相关性，校正年龄、种族/民族、教育、收入、阿司匹林使用、激素替代治疗结果使用他汀类药物的参与者的D-二聚体调整水平较低（-9%），C-反应蛋白（-21%）和凝血因子VIII（-3%）比非使用者（P
BackgroundHMG-CoA reductase inhibitors (statins) reduce the risk of venous thromboembolism (VTE) in healthy people. Statins reduce levels of inflammation biomarkers; however, the mechanism for the reduction in VTE risk is unknown.AimIn a large cohort of healthy people, we studied associations of statin use with plasma hemostatic factors related to VTE risk.MethodsCross-sectional analyses were performed in the Multi-Ethnic Study of Atherosclerosis (MESA), a cohort study of 6814 healthy men and women aged 45-84years, free of clinical cardiovascular disease at baseline; 1001 were using statins at baseline. Twenty-three warfarin users were excluded. Age, race and sex-adjusted mean hemostatic factor levels were compared between statin users and non-users, and multivariable linear regression models were used to assess associations of statin use with hemostatic factors, adjusted for age, race/ethnicity, education, income, aspirin use, hormone replacement therapy (in women), and major cardiovascular risk factors.ResultsParticipants using statins had lower adjusted levels of D-dimer (-9%), C-reactive protein (-21%) and factorVIII (-3%) than non-users (P