Infection of SARS-CoV on juvenile and adult Brandt's vole Microtus brandtii
Infection of SARS-CoV on juvenile and adult Brandt's vole Microtus brandtii
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DOI：
10.1360/982004-598
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发表时间：
2005-06-01
影响因子：
--
通讯作者：
Zhang, ZB
中科院分区：
文献类型：
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作者：
Gao, H;Peng, JP;Zhang, ZB
采用鼻腔喷雾法（CCID 50 = 10（5.7））研究了SARS冠状病毒对布氏田鼠（Microtus brandtii）幼鼠和成年鼠的感染效果。SARS病毒导致成人严重死亡。死亡成虫表现为口、鼻、肠出血，恶性间质性肺炎，肝、脾、肾戈尔。存活成虫肺内可见局部出血点及肺气肿，其他脏器未见病理改变。SARS病毒没有引起幼鱼死亡，但感染幼鱼的运动速度变慢。早期肺部有局限性肺炎，病理组织中分离到SARS病毒。只有一只对照幼鱼存活，感染幼鱼表现为肺部局部肺炎。结果表明，SARS-CoV对布氏田鼠的感染程度较重，成年布氏田鼠对SARS-CoV的抵抗力高于幼鼠。布氏田鼠可能是SARS研究的一种潜在动物模型。
We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt's Vole (Microtus brandtii) by nasal cavity spraying method (CCID50 is 10(5.7)). SARS virus caused serious deaths in adults. The death adults demonstrated hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneumonia and gore in liver, spleen and kidney. The survival adults demonstrated local hemorrhagic spot in lung and emphysema, but the other organs showed no pathological abnormality. SARS virus caused no deaths in juveniles, but locomotion of infected juveniles became slower. In the early stage, there was local pneumonia in lung and SARS viruses were isolated from the pathological tissue. Only one control juvenile lived and the infected juvenile showed local pneumonia in lung. The results demonstrated that SARS-CoV infected Brandt's vole seriously and adults were more susceptive to SARS-CoV than juveniles. The Brandt's vole may be a potential animal model for SARS research.