Recent advances in bone-targeted therapies of metastatic prostate cancer.
Recent advances in bone-targeted therapies of metastatic prostate cancer.
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DOI：
10.1016/j.ctrv.2014.04.003
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发表时间：
2014-07
影响因子：
11.8
通讯作者：
Keller, Evan T.
中科院分区：
文献类型：
--
作者：
Deng, Xiyun;He, Guangchun;Liu, Junwen;Luo, Feijun;Peng, Xiaoning;Tang, Shigang;Gao, Zhiyong;Lin, Qinlu;Keller, Jill M.;Yang, Tao;Keller, Evan T.
前列腺癌是影响全世界男性的最常见的恶性肿瘤之一，骨是进展超出器官限制的患者中最常见的转移部位。骨转移几乎是不可治愈的，并导致显著的疾病发病率和死亡率。骨提供了一个独特的微环境，其与肿瘤细胞的局部相互作用为治疗干预提供了新的靶点。一些有吸引力的分子或途径已被确定为转移性去势抵抗性前列腺癌引起的骨转移的新的潜在治疗靶点。本文就前列腺癌骨转移的分子靶向治疗的最新进展作一综述，重点介绍以骨细胞和骨微环境为靶点的治疗方法。本文综述的治疗方法包括抑制骨吸收的药物、刺激骨形成的药物和靶向骨基质的药物。提出了设计更有效的分子靶向治疗的建议。希望随着对疾病生物学的更好理解和更强大的靶向治疗的发展，受影响个体的生存和生活质量可以显着改善。
Prostate cancer is one of the most common malignancies affecting men worldwide, with bone being the most common site of metastasis in patients that progress beyond organ confinement. Bone metastases are virtually incurable and result in significant disease morbidity and mortality. Bone provides a unique microenvironment whose local interactions with tumor cells offer novel targets for therapeutic interventions. Several attractive molecules or pathways have been identified as new potential therapeutic targets for bone metastases caused by metastatic castration-resistant prostate cancer. In this review, we present the recent advances in molecular targeted therapies for prostate cancer bone metastasis focusing on therapies that target the bone cells and the bone microenvironment. The therapies covered in this review include agents that inhibit bone resorption, agents that stimulate bone formation, and agents that target the bone matrix. Suggestions to devise more effective molecular targeted therapies are proposed. Hopefully, with better understanding of the biology of the disease and the development of more robust targeted therapies, the survival and quality of life of the affected individuals could be significantly improved.
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影响因子：
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