A comparison of anticryptosporidial activity of paromomycin with that of other aminoglycosides and azithromycin in immunosuppressed rats.
A comparison of anticryptosporidial activity of paromomycin with that of other aminoglycosides and azithromycin in immunosuppressed rats.
复制标题
巴龙霉素与其他氨基糖苷类和阿奇霉素在免疫抑制大鼠中的抗隐孢子虫活性的比较。
DOI：
10.1093/infdis/170.4.934
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Rehg,JE
中科院分区：
文献类型：
--
作者：
Rehg,JE
Of six evaluated aminoglycosides, paromomycin was the only one that showed activity againstCryptosporidium parvumin immunosuppressed rats. Oral dosages ≥200 rug/kg/day reduced the severity of ileal infections; however, paromomycin was ineffective against cecal and biliary tract infections at 400 mg /kg/day orally and 50 mg /kg/day intraperitoneally. Oral paromomycin (400 mg/kg/day) was also less effective than azithromycin (400 mg/kg/day) againstCryptosporidiuminfection involving the ileum, cecum, or biliary tract of immunosuppressed rats. The data suggest that paromomycin may be an effective treatment for acute cryptosporidiosis of the small intestine but is probably ineffective against large intestine or biliary tract infections in the immunosuppressed host.
