Ontogeny and senescence of salivary immunity.
Ontogeny and senescence of salivary immunity.
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唾液免疫的个体发育和衰老。
DOI：
10.1177/00220345870660021101
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发表时间：
1987
影响因子：
7.6
通讯作者：
Ebersole,JL
中科院分区：
文献类型：
--
作者：
Smith,DJ;Taubman,MA;Ebersole,JL
本研究的目的是评估终生分泌性免疫反应的能力。这是通过单径向免疫扩散法测量年龄从2个月到91岁的受试者唾液样本中IgA和IgAI亚类的浓度来完成的。两种几乎无处不在的粘膜抗原，变形链球菌葡萄糖转移酶(GTF)和灭活的脊髓灰质炎病毒(1型、2型和3型)的唾液IgA抗体的存在，在该人群中用酶联免疫吸附试验进行了检测。2-5个月大婴儿的全唾液中的IgA含量显著低于任何成人组的腮腺唾液。此外，婴儿唾液中的IgA在总唾液中的比例明显高于成人腮腺唾液中的IgA。青年和老年(70~91岁)成人腮腺唾液中IgA和Iga亚类水平无差异。在大多数5岁以下儿童的唾液样本中，抗GTF的唾液IgA抗体水平可以忽略不计，而1岁以上儿童中有40%的唾液抗体水平可检测到脊髓灰质炎病毒(PV)。这种对GTF和PV抗原反应的差异可能反映了抗原挑战的不同。年龄最大组(70~91岁)腮腺唾液中抗这两种抗原的IgA抗体分布较窄，且均为低水平。由于他们的IgA免疫球蛋白水平与年轻人相同，这一年龄最大的群体的低抗体水平可能与T或B淋巴细胞或抗原处理细胞的数量或功能的变化有关，和/或可能是对这些抗原的攻击水平降低所致。
The objective of the present study was to evaluate the capacity for secretory immune responses throughout life. This was done by measuring, by single radial immunodiffusion, the concentrations of IgA and IgAI subclass in saliva samples of subjects who ranged in age from two months to 91 years. The presence of salivary IgA antibodies to two nearly ubiquitous mucosal antigens, Streptococcus mutans glucosyltransferase (GTF) and killed poliovirus (Types 1, 2, and 3), was measured in an enzyme-linked immunosorbent assay in this population. Whole saliva from 2-5-month-old infants contained significantly less IgA than did parotid saliva of any adult group. Also, a significantly higher proportion of the total salivary IgA was IgAI in infants' saliva than was found in parotid saliva of adults. Salivary IgA and IgAl subclass levels in parotid saliva of young and old (70-91 years) adults did not differ. Salivary IgA antibody levels to GTF were negligible in most saliva samples of children less than five years old, while 40% of children older than one year had detectable levels of salivary antibody to poliovirus (PV). This difference between response to GTF and PV antigens may reflect differences in antigenic challenge. Parotid saliva of the oldest group (70-91 years) had narrowly distributed and uniformly low levels of IgA antibody to both antigens. Since their IgA immunoglobulin levels were the same as in younger adults, the low antibody levels in this oldest group may be associated with changes in the number or function of T or B lymphocytes or antigen-processing cells, and/or may result from diminished levels of challenge with these antigens.