Amygdala lesions produce analgesia in a novel, ethologically relevant acute pain test
Amygdala lesions produce analgesia in a novel, ethologically relevant acute pain test
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DOI：
10.1016/s0031-9384(99)00042-6
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发表时间：
1999-08-01
影响因子：
2.9
通讯作者：
Blanchard, RJ
中科院分区：
文献类型：
--
作者：
Hebert, MA;Ardid, D;Blanchard, RJ
使用机械刺激的急性疼痛测试通常不涉及受试者进化史上重要的对象，并且可能无法评估生物行为防御反应对总疼痛反应的贡献。刺是植物和动物抵御捕食的常见防御结构。目前的研究在实验室大鼠身上检测了接触这种自然的、机械的疼痛刺激的反应，使用了一个位于新小巷中间的带有突出针的地板（“fakir”测试）。行为反应在10分钟的测试中被表征（实验1）。受试者自愿接触针，随后进行回避和风险评估模式（拉伸参与和拉伸方法）。很少有受试者穿过针阵。杏仁核与疼痛的感知有关，特别是在压力或恐惧的情况下。在实验2中，fakir测试同时用于检查杏仁核病变对镇痛测量（针交叉频率和持续时间）和焦虑测量（风险评估）的影响。大的，双侧的杏仁核病变显著增加了针穿过的次数和花在针上的时间，但不影响风险评估措施。这些发现表明焦虑和痛觉之间可能存在分离，而杏仁核在后者中起着重要的（非情感的）作用。(C) 1999 Elsevier Science Inc.；
Acute pain tests using mechanical stimuli typically do not involve objects important in the evolutionary history of the subjects, and may fail to evaluate the contribution of biobehavioral defensive reactions to the total pain response. Spines are common structural defenses that project plants and animals against predation. The present studies examined the reaction to contact with such natural, mechanical pain stimuli in the laboratory rat, utilizing a floor board with protruding pins located in the middle of a novel alley (the "fakir" test). Behavioral responses were characterized in 10-min tests (Experiment 1). Subjects showed voluntary contact with the pins followed by patterns of avoidance and risk assessment (Stretch attend and stretch approach). Few subjects crossed the array of pins. The amygdala has been implicated in the perception of pain, particularly in stressful or fearful contexts. In Experiment 2, the fakir test was used to examine, concurrently, the effects of amygdala lesions on analgesiometric (frequency and duration of pins crossings) and anxiometric (risk assessment) measures. Large, bilateral, lesions of the amygdala significantly increased both the number of pin crossings and time spent on the pins without affecting the risk assessment measures. These findings suggest a possible dissociation between anxiety and pain perception with an important (nonaffective) role for the amygdala in the latter. (C) 1999 Elsevier Science Inc.