A Software App for Radiotherapy with In-situ Dose-painting using high Z nanoparticles.
A Software App for Radiotherapy with In-situ Dose-painting using high Z nanoparticles.
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DOI：
10.1007/978-3-319-19387-8_151
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发表时间：
2015-06
期刊：
影响因子：
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通讯作者：
Ngwa W
中科院分区：
文献类型：
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作者：
Jermoumi M;Yucel A;Hao Y;Cifter G;Sajo E;Ngwa W
这项工作的目的是开发一个用户友好和免费下载的应用软件，可以用于建模放射治疗与原位剂量绘画（RAID）使用高Z纳米粒子（HZNP）。RAID APP是基于确定性代码以Matlab（Mathworks，Natick，MA，USA）编写的软件程序，所述确定性代码被开发用于模拟肿瘤内的肿瘤内HZNP的时空生物分布，以及响应于I-125、Pd-102、Cs-131和千伏X射线（例如50 keV和100 keV）的低剂量率（LDR）近距离放射治疗的相应剂量增强。通过RAID APP的GUI，用户将被引导到不同的功能，以计算与高风险肿瘤子体积内的NP的剂量增强和生物分布相关的各种参数。该软件是作为研究工具开发的，具有后续开发的潜力，可用于指导使用放射增敏剂（如金（Au）和铂（Pt））的剂量绘制治疗计划。
The purpose of this work is to develop an user friendly and free-to-download application software that can be employed for modeling Radiotherapy with In-situ Dose-painting (RAID) using high-Z nanoparticles (HZNPs). The RAID APP is software program written in Matlab (Mathworks, Natick, MA, USA) based on deterministic code developed to simulate the space-time intra-tumor HZNPs biodistribution within the tumor, and the corresponding dose enhancement in response to low dose rate (LDR) brachytherapy of I-125, Pd-102, Cs-131 and kilovoltage x-rays such as 50 keV and 100 keV. Through the GUI of RAID APP, the user will be directed to different features to compute various parameters related to the dose enhancement and the biodistribution of NPs within high risk tumor sub-volumes. The software was developed as tool for research purposes with potential for subsequent development to guide dose-painting treatment planning using radiosensitizers such as gold (Au) and platinum (Pt).