An efficient method for the N-debenzylation of aromatic heterocycles
An efficient method for the N-debenzylation of aromatic heterocycles
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DOI：
10.1016/s0040-4039(01)02192-x
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发表时间：
2002-01-14
影响因子：
1.8
通讯作者：
Deaton-Rewolinski, MV
中科院分区：
文献类型：
--
作者：
Haddach, AA;Kelleman, A;Deaton-Rewolinski, MV
用叔丁醇钾/DMSO和氧气在室温下处理N-苄基化杂环，以高产率干净地得到N-脱苄基产物。该方法可用于各种官能化的含氮杂环，例如咪唑、苯并咪唑、吡唑、吲唑、咔唑和吲哚。(C)2002年由Elsevier Science Ltd.出版
The treatment of N-benzylated heterocycles with potassium tert-butoxide/DMSO and oxygen at room temperature cleanly affords N-debenzylated products in high yield. This procedure can be utilized on a variety of functionalized nitrogen-containing heterocycles such as imidazoles, benzimidazoles, pyrazoles, indazoles, carbazoles, and indoles. (C) 2002 Published by Elsevier Science Ltd.