Identification of a novel Drosophila opsin reveals specific patterning of the R7 and R8 photoreceptor cells
Identification of a novel Drosophila opsin reveals specific patterning of the R7 and R8 photoreceptor cells
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DOI：
10.1016/s0896-6273(00)80243-3
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发表时间：
1996-12-01
期刊：
影响因子：
16.2
通讯作者：
Britt, SG
中科院分区：
文献类型：
--
作者：
Chou, WH;Hall, KJ;Britt, SG
复眼的功能取决于一个发育程序，该程序指定不同的细胞命运并指导不同感光细胞中光谱上不同的视蛋白的表达。Rh5是一个新的果蝇视蛋白基因，编码一种在R8感光细胞亚群中表达的具有生物活性的视色素。Rh5在R8细胞中的表达与Rh3在覆盖的R7细胞中的表达严格协调。在缺乏R7感光细胞的sevenless突变果蝇中，R8细胞中Rh5蛋白的表达被破坏，为R7和R8细胞之间负责视蛋白基因配对表达的特定发育信号提供了证据。
The function of the compound eye is dependent upon a developmental program that specifies different cell fates and directs the expression of spectrally distinct opsins in different photoreceptor cells. Rh5 is a novel Drosophila opsin gene that encodes a biologically active visual pigment that is expressed in a subset of R8 photoreceptor cells. Rh5 expression in the R8 cell of an individual ommatidium is strictly coordinated with the expression of Rh3, in the overlying R7 cell. In sevenless mutant flies, which lack R7 photoreceptor cells, the expression of the Rh5 protein in R8 cells is disrupted, providing evidence for a specific developmental signal between the R7 and R8 cells that is responsible for the paired expression of opsin genes.