Use of Electrical Stimulation at Different Current Levels to Promote Recovery After Peripheral Nerve Injury in Rats
Use of Electrical Stimulation at Different Current Levels to Promote Recovery After Peripheral Nerve Injury in Rats
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DOI：
10.1097/ta.0b013e318182351a
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发表时间：
2009-11-01
影响因子：
--
通讯作者：
Chen, Yueh-Sheng
中科院分区：
文献类型：
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作者：
Lu, Ming-Chin;Tsai, Chin-Chuan;Chen, Yueh-Sheng
背景：电刺激受损的周围神经可能有助于再生。方法：将大鼠坐骨神经残端缝合到硅橡胶管中，在其上制作10毫米的间隙。对照组不接受任何刺激。确定 1 mA、2 mA 或 4 mA 的 2 Hz 经皮电刺激是否增强近端和远端神经残端之间的再生。结果：与对照组相比，接受电治疗的组的轴突数量、神经内膜面积、总神经面积、血管数量和血管面积的平均值更大。此外，与对照组相比，接受电刺激，尤其是1mA电刺激的组具有明显更短的潜伏期、更大的振幅、更大的诱发肌肉动作电位面积和更快的传导速度。然而，在运动学步态分析中，4 mA 的电刺激会对再生神经的功能恢复产生不良反应。结论：确实，电刺激似乎对再生过程有不利影响。能促进再生神经的生长；然而，过多的直流电可能会排斥纤维的再生。这揭示了物理治疗师使用安全刺激方案进行康复目的的重要性。
Background: Electrical stimulation of damaged peripheral nerve may aid regeneration.Methods: A 10-mm gap was made in rat sciatic nerve by suturing the stumps into silicone rubber tubes. A control group received no stimulation. To determine whether 2 Hz of percutaneous electrical stimulation at 1 mA, 2 mA, or 4 mA augments regeneration between the proximal and distal nerve stumps.Results: The groups receiving electrical treatment had larger mean values of axon number, endoneurial area, total nerve area, blood vessel number, and blood vessel area compared with the controls. In addition, the group receiving electrical stimulation, especially at I mA had significantly shorter latency, larger amplitude, larger area of the evoked muscle action potentials and faster conduction velocity compared with the controls. However, electrical stimulation at 4 mA provoked adverse responses to the function recovery of regenerated nerves in the kinematic gait analysis.Conclusion: Indeed, the electrical stimulation appears to have a detrimental effect on the regeneration process. It could promote the growth of regenerating nerves; however, excessive direct current could be repulsive to regrowing fibers. This reveals the importance for physical therapists using safe stimulus protocols for rehabilitation purposes.