Mechanisms of leukocyte lipid body formation and function in inflammation
Mechanisms of leukocyte lipid body formation and function in inflammation
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DOI：
10.1590/s0074-02762005000900020
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发表时间：
2005-03-01
期刊：
影响因子：
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通讯作者：
Bandeira-Melo, Christianne
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文献类型：
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作者：
Bozza, Patrícia T;Bandeira-Melo, Christianne
一个越来越感兴趣的理解细胞信号传导的领域是参与脂质介质生成（类花生酸形成酶，磷脂酶及其调节激酶和磷酸酶）和脂质前体池的不同酶的时空方面。细胞中离散和动态位点内的信号传导组分的区室化对于磷酸化、酶活化和功能的酶促反应的特异性和效率至关重要。我们假设脂质体-可诱导的非膜结合的胞质脂质结构域-作为信号传导区室化的专门细胞内位点发挥作用，在参与炎症过程的白细胞内脂质介质形成中起主要作用。在过去的几年里，已经取得了实质性进展，证明所有参与类二十烷酸合成的酶都定位于脂体，而脂体是类二十烷酸产生的不同位点。本文就炎症相关脂质体的形成和功能机制作一综述。
An area of increasingly interest for the understanding of cell signaling are the spatio-temporal aspects of the different enzymes involved in lipid mediator generation (eicosanoid-forming enzymes, phospholipases and their regulatory kinases and phosphatases) and pools of lipid precursors. The compartmentalization of signaling components within discrete and dynamic sites in the cell is critical for specificity and efficiency of enzymatic reactions of phosphorilation, enzyme activation and function. We hypothesized that lipid bodies - inducible non-membrane bound cytoplasmic lipid domains - function as specialized intracellular sites of compartmentalization of signaling with major roles in lipid mediator formation within leukocytes engaged in inflammatory process. Over the past years substantial progresses have been made demonstrating that all enzymes involved in eicosanoid synthesis localize at lipid bodies and lipid bodies are distinct sites for eicosanoid generation. Here we will review our current knowledge on the mechanisms of formation and functions of lipid bodies pertinent to inflammation.