Application of ionic liquids based microwave-assisted simultaneous extraction of carnosic acid, rosmarinic acid and essential oil from Rosmarinus officinalis
Application of ionic liquids based microwave-assisted simultaneous extraction of carnosic acid, rosmarinic acid and essential oil from Rosmarinus officinalis
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DOI：
10.1016/j.chroma.2011.09.073
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发表时间：
2011-11-25
影响因子：
4.1
通讯作者：
Zhang, Zhonghua
中科院分区：
文献类型：
--
作者：
Liu, Tingting;Sui, Xiaoyu;Zhang, Zhonghua
采用离子液体微波辅助同时萃取蒸馏（ILMSED）法从迷迭香中提取鼠尾草酸（CA）、迷迭香酸（RA）和迷迭香精油（EO）。本文研究了一系列阴、阳离子组成不同的1-烷基-3-甲基咪唑离子液体的萃取性能。结果表明，离子液体的阴、阳离子对CA和RA的萃取均有影响，选择1.0M溴化1-辛基-3-甲基咪唑（[C8 mim]Br）溶液为溶剂。此外，对三种目标成分的ILMSED工艺进行了优化，并与其他常规提取工艺进行了比较。ILMSED由于在最短的提取时间内CA和RA的最高提取率而得到最好的结果。开发的新工艺在EO的产率和选择性以及较短的分离时间（20 min，相比于4 h的加氢蒸馏）方面提供了优势，并且提供了更有价值的EO（具有高含量的含氧化合物）。并对提取前后的迷迭香样品的显微结构和化学结构进行了研究。并通过稳定性、重复性和回收率实验对方法进行了验证。结果表明，ILMSED法为迷迭香等中草药中非挥发性成分（CA和RA）和EO的提取提供了一种很好的方法。(C)2011 Elsevier B. V.保留所有权利。
An ionic liquid based microwave-assisted simultaneous extraction and distillation (ILMSED) method has been developed for the effective extraction of carnosic acid (CA), rosmarinic acid (RA) and essential oil (EO) from Rosmarinus officinalis. A series of 1-alkyl-3-methylimidazolium ionic liquids differing in composition of anion and cation were evaluated for extraction yield in this work. The results obtained indicated that the anions and cations of ionic liquids had influences on the extraction of CA and RA, 1.0 M 1-octyl-3-methylimidazolium bromide ([C8mim]Br) solution was selected as solvent. In addition, the ILMSED procedures for the three target ingredients were optimized and compared with other conventional extraction techniques. ILMSED gave the best result due to the highest extraction yield within the shortest extraction time for CA and RA. The novel process developed offered advantages in term of yield and selectivity of EO and shorter isolation time (20 min in comparison of 4 h of hydrodistillation), and provides a more valuable EO (with high amount of oxygenated compounds). The microstructures and chemical structures of rosemary samples before and after extraction were also investigated. Moreover, the proposed method was validated by the stability, repeatability and recovery experiments. The results indicated that the developed ILMSED method provided a good alternative for the both extraction of non-volatile compounds (CA and RA) and EO from rosemary as well as other herbs. (C) 2011 Elsevier B.V. All rights reserved.