Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid Associated With Mucinous Adenocarcinoma
Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid Associated With Mucinous Adenocarcinoma
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DOI：
10.1097/iop.0000000000001002
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发表时间：
2018-03-01
影响因子：
2
通讯作者：
Lo, Christopher
中科院分区：
文献类型：
--
作者：
Charles, Norman C.;Proia, Alan D.;Lo, Christopher
内分泌型黏液汗腺癌是一种罕见的低度恶性肿瘤，好发于眼睑，被认为是浸润性黏液腺癌的前兆。内分泌型黏液分泌型汗腺癌及其并发黏液腺癌在眼科文献中很少受到关注。这两种组织学类型的结合与乳腺内分泌导管原位癌及其向B型浸润性粘液癌的转变相似。作者描述了一名59岁的男子谁开发的右上眼睑肿瘤显示内分泌粘液产生的汗腺癌在外层真皮和广泛的粘液癌在更深的组织。免疫组化分析显示肿瘤的组织学成分。本研究的进行符合赫尔辛基对内分泌标志物嗜铬粒蛋白、突触素、CD 56、雌激素和孕激素的要求。
Endocrine mucin-producing sweat gland carcinoma, a rare, low-grade neoplasm with predilection for the eyelids, has been posited as a precursor to invasive mucinous adenocarcinoma. Endocrine mucin-producing sweat gland carcinoma and its concurrence with mucinous adenocarcinoma have received little attention in the ophthalmic literature. The combination of the 2 histologic patterns parallels endocrine ductal carcinoma in situ of the breast and its transition to Type B invasive mucinous carcinoma. The authors describe a 59-year-old man who developed a tumor of the right upper eyelid showing endocrine mucin-producing sweat gland carcinoma in the outer dermis and extensive mucinous carcinoma in the deeper tissue. Immunohistochemical analysis showed po histologic component of the tumor. This research was conducted in conformity with the Helsinki Desitivity for endocrine markers chromogranin, synaptophysin, CD56, estrogen, and progesterone in eachclaration and HIPPA regulations.