PHARMACOLOGICAL CHARACTERIZATION OF PERFORMANCE ON A CONCURRENT LEVER PRESSING FEEDING CHOICE PROCEDURE - EFFECTS OF DOPAMINE ANTAGONIST, CHOLINOMIMETIC, SEDATIVE AND STIMULANT-DRUGS
PHARMACOLOGICAL CHARACTERIZATION OF PERFORMANCE ON A CONCURRENT LEVER PRESSING FEEDING CHOICE PROCEDURE - EFFECTS OF DOPAMINE ANTAGONIST, CHOLINOMIMETIC, SEDATIVE AND STIMULANT-DRUGS
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DOI：
10.1007/bf02247489
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发表时间：
1994-12-01
影响因子：
3.4
通讯作者：
SALAMONE, JD
中科院分区：
文献类型：
--
作者：
COUSINS, MS;WEI, W;SALAMONE, JD
这个实验是为了提供一个涉及食物相关的工具和完善行为的任务的药理学特征。大鼠在一个操作室中进行测试，在这个操作室中，大鼠可以选择按下杠杆来获得喜欢的食物（Bioserve颗粒），或者接近并食用不太喜欢的食物（Lab Chow）。杠杆压紧计划为固定比率5 （FR5）。大鼠通常以高速率按压杠杆来获得喜欢的食物，并且通常只吃很少的实验室食物，即使在按压杠杆的同时，实验舱里的食物是免费的。先前的研究表明，注射多巴胺（DA）拮抗剂，或消耗伏隔核中的DA，会导致行为的实质性转变，例如杠杆按压减少，但食物消耗增加。本研究表明，在0.1和0.15 mg/kg剂量下，DA拮抗剂氟哌啶醇可以减少杠杆压，增加食物消耗。D1拮抗剂SCH 23390（0.05、0.1和0.15 mg/kg）和非选择性DA拮抗剂顺式氟苯硫醇（0.3和0.45 mg/kg）降低了杠杆压，显著增加了饲料消耗。D2拮抗剂舒必利降低了杠杆压，但在最高剂量下只产生轻微的增加。戊巴比妥在10.0 mg/kg时减少了杠杆按压，增加了食物消耗。毒蕈碱激动剂匹罗卡品在杠杆压下产生剂量相关的减少，但没有增加食物消耗。安非他明在杠杆按压和食物消耗中产生剂量相关的减少。这些结果表明，低/中剂量的DA拮抗剂氟哌啶醇、顺式氟苯硫醇和SCH 23390可以抑制杠杆按压，使动物直接进入食物获取和消费。
This experiment was undertaken to provide a pharmacological characterization of performance on a task involving food-related instrumental and consummatory behavior. Rats were tested in an operant chamber in which there was a choice between pressing a lever to receive a preferred food (Bioserve pellets) or approaching and consuming a less-preferred food (Lab Chow). The lever pressing schedule was a fixed ratio 5 (FR5). Rats usually pressed the lever at high rates to obtain the preferred food, and typically ate little of the lab chow even though it was freely available in the chamber concurrently with the lever pressing schedule. Previous work has shown that injection of dopamine (DA) antagonists, or depletion of DA in the nucleus accumbens, caused a substantial shift in behavior such that lever pressing was reduced but chow consumption increased. In the present study it was shown that the DA antagonist haloperidol decreased lever pressing and increased chow consumption at doses of 0.1 and 0.15 mg/kg. The D1 antagonist SCH 23390 (0.05, 0.1 and 0.15 mg/kg) and the non-selective DA antagonist cis-flupenthixol (0.3 and 0.45 mg/kg) decreased lever pressing and produced substantial increases in chow consumption. The D2 antagonist sulpiride decreased lever pressing, but produced only slight increases in chow intake at the highest dose. Pentobarbital reduced lever pressing and increased chow consumption at 10.0 mg/kg. The muscarinic agonist pilocarpine produced dose-related decreases in lever pressing, but failed to increase chow consumption. Amphetamine produced dose-related decreases in both lever pressing and chow consumption. These results indicate that low/moderate doses of the DA antagonists haloperidol, cis-flupenthixol and SCH 23390 can suppress lever pressing in doses that leave the animal directed towards food acquisition and consumption.