An emerging consensus on cardiac regeneration.
An emerging consensus on cardiac regeneration.
复制标题
作者：
心脏再生是一个快速发展和有争议的研究领域。大约12年前，人类发现了心脏内的祖细胞，这激发了人们对基于细胞的再生疗法的热情。然而，最近的证据对心脏中生物学上重要的干细胞群的存在以及外源性来源的细胞通过直接形成新的心肌细胞来促进再生的能力提出了质疑。在这里，我们讨论了最近的事态发展，表明不同类型的细胞再生成年哺乳动物心脏的能力正在形成共识。
Cardiac regeneration is a rapidly evolving and controversial field of research. The identification some 12 years ago of progenitor cells that reside within the heart spurred enthusiasm for cell-based regenerative therapies. However, recent evidence has called into question both the presence of a biologically important stem cell population in the heart and the ability of exogenously derived cells to promote regeneration through direct formation of new cardiomyocytes. Here, we discuss recent developments that suggest an emerging consensus on the ability of different cell types to regenerate the adult mammalian heart.