Genetic and physical map of 11 short tandem repeat polymorphisms on human chromosome 6.
Genetic and physical map of 11 short tandem repeat polymorphisms on human chromosome 6.
复制标题
人类 6 号染色体上 11 个短串联重复多态性的遗传和物理图谱。
DOI：
10.1006/geno.1993.1042
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发表时间：
1993
期刊：
影响因子：
4.4
通讯作者：
Weber,JL
中科院分区：
文献类型：
--
作者：
Wilkie,PJ;Polymeropoulos,MH;Trent,JM;Small,KW;Weber,JL
构建了人类6号染色体11个短串联重复多态性的连锁图谱。从p到qter的顺序为F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S253。对于 6q 标记跨越的区域，男性图谱距离小于女性图谱距离的一半（分别为 58 和 126.3 cM）。还使用两点连锁分析来相对于 CEPH 公共数据库中的标记来定位标记。这些标记物的物理定位是使用包含 6 号染色体不同片段的体细胞杂交组完成的。其中两个标记物定位到 6 号染色体的短臂；另一个标记物定位到 6 号染色体的短臂。其余部分从 6q13 到 6qter 的长臂间隔超过 86.5 cm。联动和物理图完全一致。
A linkage map of 11 short tandem repeat polymorphisms was constructed for human chromosome 6. The order from p to qter was F131-D6S105-D6S254-D6S251-D6S252-D6S249-(ARG1-D6S87)-D6S250-D6S255-D6S253. For the region spanned by the 6q markers, the male map distance was less than half the female map distance (58 and 126.3 cM, respectively). Two-point linkage analysis was also used to position the markers relative to markers in the CEPH public database. Physical mapping of these markers was completed using a somatic cell hybrid panel that contained varying segments of chromosome 6. Two of the markers mapped to the short arm of chromosome 6; the remainder were spaced over 86.5 cM of the long arm from 6q13 to 6qter. The linkage and physical maps were completely consistent.