A LONGITUDINAL-STUDY OF SUBCHONDRAL PLATE AND TRABECULAR BONE IN CRUCIATE-DEFICIENT DOGS WITH OSTEOARTHRITIS FOLLOWED UP FOR 54 MONTHS
A LONGITUDINAL-STUDY OF SUBCHONDRAL PLATE AND TRABECULAR BONE IN CRUCIATE-DEFICIENT DOGS WITH OSTEOARTHRITIS FOLLOWED UP FOR 54 MONTHS
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DOI：
10.1002/art.1780361019
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发表时间：
1993-10-01
影响因子：
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通讯作者：
ALBRECHT, M
中科院分区：
文献类型：
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作者：
DEDRICK, DK;GOLDSTEIN, SA;ALBRECHT, M
目标。目的探讨前交叉韧带横断术(ACLT)后3个月、18个月和54个月时骨性关节炎(OA)犬关节软骨、松质骨和软骨下板的变化规律。在分辨率为60am的条件下，对胫骨内侧平台标本进行显微计算机断层扫描(Micro-CT)分析，并检测股骨关节软骨的生化和形态变化。在ACLT后3个月和18个月，不稳定膝关节的关节软骨表现出典型的早期OA的组织学变化，水分含量和尿酸浓度增加；到54个月时，全层溃疡已经形成。Micro-CT分析显示，与对侧膝关节相比，在所有时间点，不稳定膝关节的松质骨丢失。在18个月和54个月，骨小梁厚度和表面积/体积比的差异都大于3个月。虽然ACLT术后18个月和54个月，OA膝关节的平均软骨下板厚，尤其是胫骨内侧平台的厚度明显大于对侧膝关节，但差异无统计学意义；但54个月时的差异显著大于3个月时的差异。在该模型中，软骨下骨的增厚不是骨性关节炎软骨发生变化的必要条件。然而，ACLT后发生的骨质变化可能会导致应力异常传递到覆盖的软骨，从而导致软骨退化的进展。
Objective. To evaluate the sequence of changes in articular cartilage, trabecular bone, and subchondral plate in dogs with osteoarthritis (OA), 3 months, 18 months, and 54 months after anterior cruciate ligament transection (ACLT).Methods. Specimens of the medial tibial plateau were analyzed with microscopic computed tomography (micro-CT) at a resolution of 60 Am, and biochemical and morphologic changes in the femoral articular cartilage were assessed.Results. At 3 months and 18 months after ACLT, the articular cartilage in the unstable knee showed histologic changes typical of early OA and increased water content and uronic acid concentration; by 54 months, full-thickness ulceration had developed. Micro-CT analysis showed a loss of trabecular bone in the unstable knee, compared with the contralateral knee, at all time points. At both 18 and 54 months, the differences in trabecular thickness and surface-to-volume ratio were greater than at 3 months. Although the mean subchondral plate thickness, especially in the medial aspect of the medial tibial plateau, was greater in the OA knee than in the contralateral knee 18 months and 54 months after ACLT, these differences were not statistically significant; however, the difference was significantly greater at 54 months than at 3 months.Conclusion. Thickening of the subchondral bone is not required for the development of cartilage changes of OA in this model. The bony changes that develop after ACLT, however, could result in abnormal transmission of stress to the overlying cartilage and thereby contribute to the progression of cartilage degeneration.