Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats
Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats
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DOI：
10.1016/j.bbr.2007.08.035
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发表时间：
2008-02
影响因子：
2.7
通讯作者：
D. Tait;V. Brown
中科院分区：
文献类型：
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作者：
D. Tait;V. Brown
基底前脑的胆碱能神经元投射到皮质、丘脑网状核和杏仁核，参与注意功能的许多方面，而基底前脑的内在神经元参与学习和记忆。本研究比较了用免疫毒素192-IgG-皂草素（其选择性地破坏胆碱能神经元）或非选择性兴奋性毒素鹅膏蕈氨酸（其破坏胆碱能和非胆碱能神经元）对基底前脑进行的损伤对测量注意力集的获得和转移以及学习特定刺激-奖励配对的逆转的能力的任务的影响。老鼠学会了通过在含有独特的挖掘介质的小碗中挖掘来获得食物奖励，这些挖掘介质具有不同的气味。他们进行了一系列二选一的辨别，诱饵与气味或挖掘介质有关。在任务的任何阶段，相对于对照组大鼠，基底前脑具有192-IgG-皂草素病变的大鼠均未受损。鹅膏蕈氨酸损伤的大鼠基底前脑受损的第一次刺激奖励意外事件被逆转。他们在获得新的歧视方面没有受到损害，即使需要注意力转移。这些数据与来自绒猴的数据一致，因此突出了猴和啮齿动物基底前脑的功能相似性。他们还证实了基底前脑的非胆碱能神经元可能参与逆转学习。
The cholinergic neurons of the basal forebrain, which project to cortex, the thalamic reticular nucleus and the amygdala, are implicated in many aspects of attentional function, while the intrinsic neurons of the basal forebrain are implicated in learning and memory. This study compared the effects of lesions of the basal forebrain made with either the immunotoxin 192-IgG-saporin (which selectively destroys cholinergic neurons), or the non-selective excitotoxin, ibotenic acid (which destroys both cholinergic and non-cholinergic neurons) on a task which measure the acquisition and shifting of attentional set as well as the ability to learn reversals of specific stimulus-reward pairings. Rats learned to obtain food reward by digging in small bowls containing distinctive digging media that were differentially scented with distinct odours. They performed a series of two-choice discriminations, with the bait associated with either the odour or the digging medium. Rats with 192-IgG-saporin lesions of the basal forebrain were not impaired relative to control rats at any stage of the task. Rats with ibotenic acid lesions of the basal forebrain were impaired the first time stimulus-reward contingencies were reversed. They were not impaired in acquisition of new discriminations, even when an attentional-shift was required. These data are consistent with data from marmosets and so highlight the functional similarity of monkey and rodent basal forebrain. They also confirm the likely involvement of non-cholinergic neurons of the basal forebrain in reversal learning.