Effects of NMDA receptor antagonists on cocaine-conditioned motor activity in rats.
Effects of NMDA receptor antagonists on cocaine-conditioned motor activity in rats.
复制标题
NMDA 受体拮抗剂对大鼠可卡因条件运动活动的影响。
DOI：
10.1016/s0014-2999(99)00927-9
复制
发表时间：
2000
影响因子：
5
通讯作者：
Balster,RL
中科院分区：
文献类型：
--
作者：
Bespalov,AY;Dravolina,OA;Zvartau,EE;Beardsley,PM;Balster,RL
NMDA receptor antagonists have been reported to affect learned behaviors conditioned with abused drugs, with the outcome dependent, in part, on the class of NMDA receptor antagonist used. The present study tested the ability of various site-selective NMDA receptor antagonists to modify cocaine-conditioned motor activity. Two procedures were used for independently assessing drug effects on spontaneous activity and expression of cocaine-conditioned behavior. In the conditioning experiments, rats were administered i.p. injections of cocaine (30 mg/kg) or saline paired with distinctive environments. Spontaneous horizontal activity was dose-dependently enhanced by dizocilpine (0.03–0.3 mg/kg) and memantine (1–30 mg/kg), but not by d-CPPene (3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid; SDZ EAA 494; 1–10 mg/kg), ACEA-1021 (5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione; 3–56 mg/kg), or eliprodil (3–30 mg/kg). Higher doses of memantine, d-CPPene (1–10 mg/kg), eliprodil (3–30 mg/kg), or ACEA-1021 reduced vertical activity. Following five cocaine-environment pairings, rats displayed significant increases in motor activity when exposed to the cocaine-paired environment. The following antagonists were administered prior to the conditioning test: dizocilpine (MK-801; 0.03–0.1 mg/kg), memantine (1–10 mg/kg), d-CPPene (0.3–3 mg/kg), ACEA-1021 (3–10 mg/kg), and eliprodil (1–10 mg/kg). Of these, memantine, ACEA-1021 and, to the lesser degree, eliprodil attenuated expression of cocaine-conditioned motor activity at doses that did not significantly affect spontaneous motor activity. These results show that cocaine-conditioned behaviors can be selectively modulated by some, but not all, NMDA receptor antagonists.
