Metabolic effects of sleep disruption, links to obesity and diabetes.
Metabolic effects of sleep disruption, links to obesity and diabetes.
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DOI：
10.1097/med.0000000000000082
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Scheer FA
中科院分区：
文献类型：
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作者：
Nedeltcheva AV;Scheer FA
强调睡眠中断的不良代谢影响，并为旨在预防措施的研究开辟道路。考虑到自愿睡眠缩短、睡眠障碍、糖尿病和肥胖症的日益普遍，这一研究领域尤其相关。流行病学研究已经确定了自我报告的睡眠时间减少与2型糖尿病（T2 D），肥胖和心血管疾病发病率增加之间的关联。实验室研究表明，减少睡眠量或睡眠质量会降低胰岛素敏感性和葡萄糖耐量。实验性的睡眠限制也会导致生理和行为的变化，促进积极的能量平衡。虽然睡眠限制会因清醒增加而增加能量消耗，但它会导致食物摄入量不成比例地增加，身体活动减少和体重增加。睡眠中断对代谢健康有不利影响。这些见解可能有助于开发基于提高睡眠质量和/或数量的针对肥胖和T2 D的新预防和治疗方法。
To highlight the adverse metabolic effects of sleep disruption and to open ground for research aimed at preventive measures. This area of research is especially relevant given the increasing prevalence of voluntary sleep curtailment, sleep disorders, diabetes, and obesity. Epidemiological studies have established an association between decreased self-reported sleep duration and an increased incidence of type 2 diabetes (T2D), obesity, and cardiovascular disease. Experimental laboratory studies have demonstrated that decreasing either the amount or quality of sleep decreases insulin sensitivity and decreases glucose tolerance. Experimental sleep restriction also causes physiological and behavioral changes that promote a positive energy balance. While sleep restriction increases energy expenditure due to increased wakefulness, it can lead to a disproportionate increase in food intake, decrease in physical activity, and weight gain. Sleep disruption has detrimental effects on metabolic health. These insights may help in the development of new preventative and therapeutic approaches against obesity and T2D based on increasing the quality and/or quantity of sleep.