Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
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DOI：
10.1016/j.ijantimicag.2003.07.022
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发表时间：
2004-04-01
影响因子：
10.8
通讯作者：
Castilla, V
中科院分区：
文献类型：
--
作者：
Matanic, VCA;Castilla, V
评价抗微生物阳离子肽：天蚕素A、蜂毒肽、爪蟾抗菌肽I和11以及吲哚菌素对沙粒病毒朱宁病毒（QV）和单纯疱疹病毒1型（HSV-1）和2型（HSV-2）的体外抗病毒活性。天蚕抗菌肽A能有效抑制JV增殖，但不能影响HSV的复制，而蜂毒肽能抑制JV和HSV的增殖，但对宿主细胞有很高的毒性。爪蟾抗菌素I和II对HSV-1和HSV-2有抑制作用，但对JV无活性。只有indolicidin显示出对无细胞病毒原液的直接灭活作用。除其对JV复制的抑制作用外，天蚕素A还对沙粒病毒Tacaribe和Pichinde有活性，主要通过阻止病毒形态发生和从感染细胞中排出来影响沙粒病毒增殖周期的晚期事件。(C)2004年，Elsevier B. V.和国际化疗学会。All rights reserved.
The in vitro antiviral activity of antimicrobial cationic peptides: cecropin A, melittin, magainin I and 11 and indolicidin against the arenavirus Junin virus QV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated. Cecropin A effectively inhibited JV multiplication and failed to affect HSV replication whereas melittin impeded the multiplication of JV and HSV, but was highly toxic for the host cell. Magainins I and II exhibited inhibitory action toward HSV-1 and HSV-2 but were inactive against JV. Only indolicidin showed a direct inactivation effect on cell-free virus stocks. Besides its inhibitory effect on JV replication cecropin A also was active against the arenaviruses Tacaribe and Pichinde, mainly affecting late events of arenavirus multiplication cycle by preventing viral morphogenesis and egress from infected cells. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.