BACTERIOFERRITINS AND FERRITINS ARE DISTANTLY RELATED IN EVOLUTION - CONSERVATION OF FERROXIDASE-CENTER RESIDUES
BACTERIOFERRITINS AND FERRITINS ARE DISTANTLY RELATED IN EVOLUTION - CONSERVATION OF FERROXIDASE-CENTER RESIDUES
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DOI：
10.1016/0014-5793(91)81177-a
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发表时间：
1991-11-18
期刊：
影响因子：
3.5
通讯作者：
HARRISON, PM
中科院分区：
文献类型：
--
作者：
ANDREWS, SC;SMITH, JMA;HARRISON, PM
铁储存蛋白可分为两类：细菌铁蛋白和铁蛋白。尽管有许多明显的结构和功能的相似性，没有显着的氨基酸序列相似性已被检测到。这份报告现在揭示了细菌铁蛋白和铁蛋白之间的遥远的进化关系，由“配置文件分析”得出。细菌铁蛋白和铁蛋白序列的最佳比对表明铁蛋白的铁氧化酶中心的关键残基在细菌铁蛋白中是保守的。
Iron-storage proteins can be divided into two classes; the bacterioferritins and ferritins. In spite of many apparent structural and functional analogies, no significant amino acid sequence similarity has been detected previously. This report now reveals a distant evolutionary relationship between bacterioferritins and ferritins derived by 'Profile Analysis'. Optimum alignment of bacterioferritin and ferritin sequences suggests that key residues of the ferroxidase centres of ferritins are conserved in bacterioferritins.