IMPAIRED BLADDER PERFUSION IN INTERSTITIAL CYSTITIS - A STUDY OF BLOOD-SUPPLY USING LASER DOPPLER FLOWMETRY
IMPAIRED BLADDER PERFUSION IN INTERSTITIAL CYSTITIS - A STUDY OF BLOOD-SUPPLY USING LASER DOPPLER FLOWMETRY
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DOI：
10.1016/s0022-5347(17)36253-5
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发表时间：
1993-04-01
影响因子：
6.6
通讯作者：
GALLOWAY, NTM
中科院分区：
文献类型：
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作者：
IRWIN, P;GALLOWAY, NTM
应用激光多普勒血流仪对16例间质性膀胱炎患者和18例对照者的膀胱血流进行了研究。所有研究均在全身麻醉下进行膀胱镜检查。间质性膀胱炎患者符合国家糖尿病、消化和肾脏疾病研究所（NIDDK）的诊断标准。在膀胱中的四个特定部位以100 ml的容量进行血流量测量。而且是满负荷运转麻醉下的平均最大容量为828 cc的对照组和562 ce的IC组。两组在低容量时的血流量相似。当膀胱充盈至容量时，对照组的血流量平均增加9.05 LDF单位，但IC组仅增加0.06 LDF单位（p = 0.007）。与IC组相比，对照组的穹窿灌注增加显著更多（p = 0.002）。两组中穹窿与三角灌注的平均比率相似，并且不受伴随扩张的总体血流变化的影响。尽管对照组麻醉下的平均膀胱容量更大，但协变量分析表明，两组之间灌注的显著差异独立于容量的变化。
Laser doppler flowmetry was used to study bladder blood flow in 16 patients with interstitial cystitis and in 18 control subjects. All studies were performed at cystoscopy under general anesthesia. Interstitial cystitis patients conformed to the diagnostic criteria of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Blood flow measurements were made at, four specific sites in the bladder at a capacity of 100 ml. and at full capacity. The mean maximum capacity under anesthesia was 828 cc for the control group and 562 ce for the IC group. Blood flow at low capacity was similar in the two groups. When the bladder was filled to capacity, blood flow increased by a mean of 9.05 LDF units in the control group but only by 0.06 LDF units in the IC group (p = 0.007). Vault perfusion increased considerably more in the control group compared to the IC group (p = 0.002). The mean ratio of vault to trigonal perfusion was similar in both groups and was not affected by the overall blood flow changes which accompanied distension. Although the mean bladder capacity under anesthesia was greater in the control group, covariant analysis showed that the significant differences in perfusion between the two groups occurred independently of changes in capacity.