WINE AND TOBACCO - RISK-FACTORS FOR GASTRIC-CANCER IN FRANCE
WINE AND TOBACCO - RISK-FACTORS FOR GASTRIC-CANCER IN FRANCE
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DOI：
10.1093/oxfordjournals.aje.a113146
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发表时间：
1981-01-01
影响因子：
5
通讯作者：
LAMBERT, R
中科院分区：
文献类型：
--
作者：
HOEY, J;MONTVERNAY, C;LAMBERT, R
法国的横断面研究表明，酒精相关疾病的死亡率与胃癌的死亡率之间存在很强的区域相关性。本研究包括40例新诊断的胃腺癌和168例对照组，在同一时间段，1978-1980年，从同一医院服务中选择4种其他胃肠道诊断之一。根据标准的营养访谈，酒精，特别是红酒是这种癌症的重要风险因素（酒精的相对风险为6.9，95%置信限（CL）为3.3-14.3，葡萄酒的相对风险为6.3，CL为3.1-12.7）。每天吸烟一根或多根与胃癌的相对危险度为4.8相关，CL为1.6-14.8。两种风险因素的存在与相对风险9.3相关，95% CL为4.6-19.0。年龄、吸烟和吃生菜（在其他研究中报告的胃癌保护因素）的可能混杂因素不能解释这些结果。当对照组的每个诊断组分别进行分析时，相对风险被一致地发现并保持显著性。酒精，尤其是红酒，可能是法国胃腺癌的重要危险因素。吸烟本身就是一个危险因素，如果再加上酒精，似乎会显着增加风险。
Cross-sectional studies in France have shown strong regional correlations between death rates from alcohol related diseases and death rates from gastric cancer. The present study involved 40 cases of newly diagnosed adenocarcinoma of the stomach and 168 control subjects with 1 of 4 other gastrointestinal diagnoses selected from the same hospital service during the same time period, 1978-1980. Based on a standard nutritional interview, alcohol and particularly red wine were significant risk factors for this cancer (relative risks of 6.9 with 95% confidence limits (CL) of 3.3-14.3 for alcohol and 6.3 with CL 3.1-12.7 for wine). Smoking of one or more cigarettes per day was associated with a relative risk for gastric cancer of 4.8 with CL of 1.6-14.8. The presence of both risk factors was associated with a relative risk of 9.3 with 95% CL of 4.6-19.0. Possible confounding by age, smoking and eating lettuce (a reported protective factor for gastric cancer in other studies) did not explain these results. The relative risks were consistently found and remained significant when each diagnostic group of control subjects was analyzed separately. Alcohol, and particularly red wine, may be important risk factors for adenocarcinoma of the stomach in France. Cigarette smoking, a risk factor in itself when coupled with alcohol, appears to markedly increase the risk.