SERCA2a in heart failure: Role and therapeutic prospects
SERCA2a in heart failure: Role and therapeutic prospects
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DOI：
10.1007/s10863-005-9474-z
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发表时间：
2005-12-01
影响因子：
3
通讯作者：
Hajjar, RJ
中科院分区：
文献类型：
--
作者：
Gianni, D;Chan, J;Hajjar, RJ
Ca2+是控制所有细胞类型中从受精到细胞死亡的几个细胞过程的关键分子。在可兴奋和收缩的细胞中，如心肌细胞，Ca 2+控制肌肉收缩性。Ca2+浓度的空间和时间分离对于维持其在细胞和细胞区室中的浓度梯度以实现适当功能是至关重要的。SERCA2a是用于在心动周期期间维持Ca2+的平衡浓度的基石，因为它控制在松弛期间Ca2+向肌浆网（SR）的转运。该泵活性的改变已被广泛研究，强调其在控制Ca2+稳态中的中心作用，并因此在心力衰竭所见的收缩缺陷的发病机制中。本文就SERCA2a的分子特性、在心脏周期中的作用以及调控SERCA2a在心力衰竭治疗中的应用前景作一综述。
Ca2+ is a key molecule controlling several cellular processes, from fertilization to cell death, in all cell types. In excitable and contracting cells, such as cardiac myocytes, Ca2+ controls Muscle contractility. The spatial and temporal segregation of Ca2+ concentrations are central to maintain its concentration gradients across the cells and thee Cellular compartments for proper function. SERCA2a is a cornerstone irioleCiAle for maintaining a balanced concentration of Ca2+ during the cardiac cycle, since it controls the transport of Ca2+ to the sarcoplasmic reticulum (SR) during relaxation. Alterations of the activity of this pump have been widely investigated, emphasizing its central role in the control of Ca2+ homeostasis and consequently in the pathogenesis of the contractile defect seen with heart failure. This review focuses on the molecular characteristics of the pump, its role during the cardiac cycle and the prospects derived from the Manipulation of SERCA2a for heart failure treatment.